Whole genome sequencing of emerging multidrug resistant Candida auris isolates in India demonstrates low genetic variation

New Microbes and New Infections
Cheshta SharmaAnuradha Chowdhary

Abstract

Candida auris is an emerging multidrug resistant yeast that causes nosocomial fungaemia and deep-seated infections. Notably, the emergence of this yeast is alarming as it exhibits resistance to azoles, amphotericin B and caspofungin, which may lead to clinical failure in patients. The multigene phylogeny and amplified fragment length polymorphism typing methods report the C. auris population as clonal. Here, using whole genome sequencing analysis, we decipher for the first time that C. auris strains from four Indian hospitals were highly related, suggesting clonal transmission. Further, all C. auris isolates originated from cases of fungaemia and were resistant to fluconazole (MIC >64 mg/L).

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Methods Mentioned

BETA
PCR

Software Mentioned

Bagheera
strip Subset ‘
SSPACE
Filler
MAUVE
Velvet
Genome Analysis Toolkit package
ES
tRNA scan - SE
RNA mmer

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