Whole-genome sequencing of the efficient industrial fuel-ethanol fermentative Saccharomyces cerevisiae strain CAT-1.

Molecular Genetics and Genomics : MGG
Farbod BabrzadehBoris U Stambuk

Abstract

The Saccharomyces cerevisiae strains widely used for industrial fuel-ethanol production have been developed by selection, but their underlying beneficial genetic polymorphisms remain unknown. Here, we report the draft whole-genome sequence of the S. cerevisiae strain CAT-1, which is a dominant fuel-ethanol fermentative strain from the sugarcane industry in Brazil. Our results indicate that strain CAT-1 is a highly heterozygous diploid yeast strain, and the ~12-Mb genome of CAT-1, when compared with the reference S228c genome, contains ~36,000 homozygous and ~30,000 heterozygous single nucleotide polymorphisms, exhibiting an uneven distribution among chromosomes due to large genomic regions of loss of heterozygosity (LOH). In total, 58 % of the 6,652 predicted protein-coding genes of the CAT-1 genome constitute different alleles when compared with the genes present in the reference S288c genome. The CAT-1 genome contains a reduced number of transposable elements, as well as several gene deletions and duplications, especially at telomeric regions, some correlated with several of the physiological characteristics of this industrial fuel-ethanol strain. Phylogenetic analyses revealed that some genes were likely associated with trai...Continue Reading

References

Oct 1, 1991·Current Opinion in Genetics & Development·J R Broach
Oct 5, 1990·Journal of Molecular Biology·S F AltschulD J Lipman
Oct 25, 1996·Science·A GoffeauS G Oliver
Dec 1, 1996·Computer Applications in the Biosciences : CABIOS·X Huang, J Zhang
Apr 16, 1998·Applied Microbiology and Biotechnology·A C CodónM Korhola
Sep 6, 2000·Trends in Genetics : TIG·R C Hardison
Mar 30, 2002·Science·Rachel B BremLeonid Kruglyak
Apr 12, 2002·The Journal of Biological Chemistry·Bassel Akache, Bernard Turcotte
Oct 10, 2002·Cell·Arend Sidow
Aug 6, 2003·European Journal of Biochemistry·Héctor Riveros-RosasEnrique Piña
Nov 19, 2003·PLoS Biology·Ross C Hardison
Feb 5, 2004·Genome Biology·Stefan KurtzSteven L Salzberg
Dec 25, 2004·Biostatistics·Pei WangRobert Tibshirani
Aug 2, 2005·Nature·Marcel MarguliesJonathan M Rothberg
Jan 28, 2006·Science·Alexander E FarrellDaniel M Kammen
Feb 10, 2007·Science·José Goldemberg
Jul 27, 2007·Proceedings of the National Academy of Sciences of the United States of America·Wu WeiLars M Steinmetz
Sep 7, 2007·PLoS Biology·Samuel LevyJ Craig Venter
Sep 29, 2007·Proceedings of the National Academy of Sciences of the United States of America·Yu LiInger K Damon
Apr 18, 2008·PLoS Biology·Erin N Smith, Leonid Kruglyak
Aug 30, 2008·FEMS Yeast Research·Luiz C BassoMario L Lopes
Sep 10, 2008·FEMS Yeast Research·Anthony R BornemanPaul J Chambers
Feb 13, 2009·Nature·Gianni LitiEdward J Louis
Feb 19, 2009·Proceedings of the National Academy of Sciences of the United States of America·Oren LitvinDana Pe'er
Feb 20, 2009·Molecular Systems Biology·Shadia ZamanJames R Broach
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Maite NovoSylvie Dequin
Oct 9, 2009·Genome Research·Juan Lucas ArguesoGonçalo A G Pereira
Feb 5, 2010·BMC Genomics·Carlos L ArayaStanley Fields
Feb 6, 2010·Science·Satoru IdeTakehiko Kobayashi
Apr 24, 2010·Science·Robin D DowellCharles Boone

❮ Previous
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Citations

Dec 29, 2012·Applied Microbiology and Biotechnology·Bianca Eli Della-BiancaAndreas Karoly Gombert
Sep 26, 2013·Antonie van Leeuwenhoek·B E Della-Bianca, A K Gombert
Sep 13, 2014·Genome Biology and Evolution·Yudong LiZhenguo Lin
Nov 5, 2014·Genome Biology and Evolution·Dana J WohlbachAudrey P Gasch
Jan 7, 2016·DNA Research : an International Journal for Rapid Publication of Reports on Genes and Genomes·Miki OkunoTakehiko Itoh
Dec 12, 2012·Trends in Genetics : TIG·Anthony R BornemanIsak S Pretorius
Sep 6, 2012·Current Opinion in Biotechnology·Anthony R BornemanPaul J Chambers
Dec 15, 2015·FEMS Yeast Research·Wesley Leoricy MarquesAndreas Karoly Gombert
Jan 13, 2015·Current Opinion in Biotechnology·Andreas K Gombert, Antonius J A van Maris
Jun 15, 2013·Yeast·Ana Teresa B F AntonangeloDébora Colombi
Aug 1, 2015·Genome Announcements·Burragoni Sravanthi Goud, Kandasamy Ulaganathan
Jan 1, 2012·Computational and Structural Biotechnology Journal·Markus Herrgård, Gianni Panagiotou
Sep 1, 2016·Journal of Proteomics·Renata M SantosElis C A Eleutherio
Nov 8, 2016·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Mario Lucio LopesHenrique Vianna de Amorim
Feb 14, 2015·Genome Announcements·Kandasamy UlaganathanJatoth Balsingh
Apr 1, 2017·Genome Announcements·Natalia CoutounéJuliana Velasco de Castro Oliveira
Oct 11, 2017·Applied Microbiology and Biotechnology·Jens Christian NielsenThiago Olitta Basso
Dec 19, 2019·Preparative Biochemistry & Biotechnology·Valkirea Matos Nascimento, Gustavo Graciano Fonseca
Jan 7, 2021·FEMS Yeast Research·Sandra Regina Ceccato-Antonini, Elizabete Aparecida Covre
Jan 9, 2021·FEMS Yeast Research·Sheila Tiemi NagamatsuMarcelo Falsarella Carazzolle
Apr 10, 2021·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Ane Catarine Tosi CostaPatricia M B Fernandes
Apr 8, 2021·FEMS Yeast Research·Carla Inês Soares RodriguesAndreas K Gombert
Jun 23, 2021·Essays in Biochemistry·Ana Paula JacobusAndreas Karoly Gombert

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