Whole-globe biomechanics using high-field MRI

Experimental Eye Research
Andrew P VoorheesIan A Sigal

Abstract

The eye is a complex structure composed of several interconnected tissues acting together, across the whole globe, to resist deformation due to intraocular pressure (IOP). However, most work in the ocular biomechanics field only examines the response to IOP over smaller regions of the eye. We used high-field MRI to measure IOP induced ocular displacements and deformations over the whole globe. Seven sheep eyes were obtained from a local abattoir and imaged within 48 h using MRI at multiple levels of IOP. IOP was controlled with a gravity perfusion system and a cannula inserted into the anterior chamber. T2-weighted imaging was performed to the eyes serially at 0 mmHg, 10 mmHg, 20 mmHg and 40 mmHg of IOP using a 9.4 T MRI scanner. Manual morphometry was conducted using 3D visualization software to quantify IOP-induced effects at the globe scale (e.g. axial length and equatorial diameters) or optic nerve head scale (e.g. canal diameter, peripapillary sclera bowing). Measurement sensitivity analysis was conducted to determine measurement precision. High-field MRI revealed an outward bowing of the posterior sclera and anterior bulging of the cornea due to IOP elevation. Increments in IOP from 10 to 40 mmHg caused measurable increas...Continue Reading

Citations

Jul 20, 2018·Investigative Ophthalmology & Visual Science·Alexandra GogolaIan A Sigal
Oct 2, 2020·Investigative Ophthalmology & Visual Science·Bryn L BrazileIan A Sigal
May 31, 2018·Investigative Ophthalmology & Visual Science·Huong TranIan A Sigal
Aug 15, 2019·Progress in Retinal and Eye Research·Craig BooteMichael J A Girard
Apr 17, 2018·Experimental Eye Research·Ning-Jiun JanIan A Sigal
Aug 20, 2021·Investigative Ophthalmology & Visual Science·Max K ColbertKevin C Chan

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