Whole-grain consumption and chronic disease: protective mechanisms

Nutrition and Cancer
J L SlavinL Marquart

Abstract

Dietary guidance recommends consumption of whole grains to reduce the risk of chronic diseases including cancer and cardiovascular disease. Epidemiologic studies support the belief that whole grains are protective against cancers, especially gastrointestinal cancers such as gastric and colonic, and cardiovascular disease. Components in whole grains that may be protective are diverse and include compounds that affect the gut environment, i.e., dietary fiber, resistant starch, and other undigestible compounds in whole grains, compounds that function as antioxidants such as trace minerals and phenolic compounds, and compounds that are phytoestrogens with potential hormonal effects. Many of the protective compounds in whole grains are also in fruits and vegetables, but some plant compounds are more concentrated in whole grains, such as phenolic compounds including ferulic and caffeic acid. Other potential mechanistic effects of whole grains include binding of carcinogens and modulation of glycemic index. Clearly, the range of protective substances in whole grains is impressive, and advice to consume additional whole grains is justifiable.

References

Mar 1, 1992·The Journal of Steroid Biochemistry and Molecular Biology·H AdlercreutzT Hase
Jan 1, 1991·Nutrition and Cancer·L U ThompsonF Cheung
Nov 1, 1991·Cancer Causes & Control : CCC·K A Steinmetz, J D Potter
Sep 1, 1991·Cancer Causes & Control : CCC·K A Steinmetz, J D Potter
Oct 20, 1990·BMJ : British Medical Journal·G WilcoxG Medley
Jan 1, 1990·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·H Adlercreutz
Jan 1, 1989·Bibliotheca nutritio et dieta·C Cantarelli
Jan 1, 1989·World Review of Nutrition and Dietetics·B PedersenB O Eggum
Jan 5, 1989·The New England Journal of Medicine·J M HarigC M Wood
Jan 1, 1985·The Journal of Applied Bacteriology·S P BorrielloA M Lawson
Jan 1, 1986·Journal of Steroid Biochemistry·H AdlercreutzA Ollus
Mar 1, 1988·American Journal of Public Health·B H Patterson, G Block
Nov 1, 1984·Postgraduate Medical Journal·J H Cummings
Sep 1, 1982·Journal of Reproduction and Fertility·A P Waters, J T Knowler
Mar 1, 1983·Journal of Steroid Biochemistry·E K HämäläinenP Pietinen
Jan 1, 1982·Advances in Food Research·N R ReddyD K Salunkhe
Aug 1, 1983·The Journal of Nutrition·K L WrickL R Hackler
Jan 1, 1984·Journal of Steroid Biochemistry·E HämäläinenP Pietinen
Dec 16, 1982·The New England Journal of Medicine·B R GoldinM N Woods
Jan 1, 1995·Critical Reviews in Food Science and Nutrition·B HalliwellO I Aruoma
Jun 1, 1995·Journal of the American Dietetic Association·A M Albertson, R C Tobelmann
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·G H Anderson
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·S WelshC Davis
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·L U Thompson
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·A M Stephen
Jan 1, 1994·Critical Reviews in Food Science and Nutrition·N E Schwartz
Jul 1, 1994·The American Journal of Clinical Nutrition·J W LampeJ L Slavin
Sep 1, 1994·The American Journal of Clinical Nutrition·A CassidyK D Setchell
Mar 1, 1994·The American Journal of Clinical Nutrition·I BjörckN G Asp
Jan 15, 1994·International Journal of Cancer. Journal International Du Cancer·P A Baghurst, T E Rohan
Jan 1, 1993·Nutrition and Cancer·E Graf, J W Eaton
Jan 1, 1995·Nutrition and Cancer·D R JacobsL Marquart
Sep 1, 1982·Applied and Environmental Microbiology·A ChessonR J Wallace

❮ Previous
Next ❯

Citations

Jul 10, 1999·International Journal of Cancer. Journal International Du Cancer·N PotischmanL A Brinton
Nov 1, 2011·Plant Foods for Human Nutrition·Lia HernándezCarlos Díaz
Jun 1, 2010·Journal of Food Science and Technology·Arun Kumar Verma, Rituparna Banerjee
Sep 13, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Francesca ChiaffarinoCarlo La Vecchia
Jul 3, 1998·Critical Reviews in Oncology/hematology·M A MooreH Tsuda
Oct 10, 2001·The British Journal of Nutrition·D R Jacobs
Dec 25, 2002·The British Journal of Nutrition·James W Anderson, Amy W Major
May 13, 2003·The Proceedings of the Nutrition Society·James W Anderson
May 13, 2003·The Proceedings of the Nutrition Society·Maureen A MurtaughLeonard Marquart
Sep 26, 2003·The Proceedings of the Nutrition Society·A T SmithC J Seal
May 20, 1998·Nutrition and Cancer·D R JacobsL H Kushi
Feb 22, 2000·Journal of the American College of Nutrition·B BruceS K Gallagher
Oct 7, 2000·Journal of the American College of Nutrition·J W AndersonD J Jenkins
Oct 7, 2000·Journal of the American College of Nutrition·J A FooteR B Harris
Jun 30, 2000·Journal of the American College of Nutrition·J W AndersonR J Kryscio
Jun 30, 2000·Journal of the American College of Nutrition·L E ClevelandJ D Goldman
Feb 14, 2004·Journal of the American College of Nutrition·James W AndersonDavid J A Jenkins
Sep 22, 2005·Acta Pharmacologica Sinica·Feng XuYong-su Zhen
Oct 26, 2005·Thorax·C TabakH A Smit
Oct 17, 2009·American Journal of Public Health·Rebecca S MozaffarianSteven L Gortmaker
Feb 12, 2011·Food & Nutrition Research·Herman Adlercreutz
Aug 5, 2011·The American Journal of Clinical Nutrition·Josiemer MatteiHannia Campos
Jun 2, 2015·Journal of Food Science and Technology·Anshu SinghRintu Banerjee
Nov 28, 2009·Nutrition Reviews·Mohsen Meydani
Sep 13, 2000·American Journal of Public Health·S LiuW C Willett
Jan 7, 1999·Drug Development and Industrial Pharmacy·M K Kottke
Nov 4, 2000·Expert Opinion on Investigational Drugs·H Wiseman
Apr 20, 2001·Critical Reviews in Biotechnology·J L SlavinL Marquart
Jul 19, 2015·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Luisa PozzoVincenzo Longo
Apr 15, 2008·Critical Reviews in Food Science and Nutrition·Fotini Arvaniti, Demosthenes B Panagiotakos
Feb 20, 2015·Journal of Food Science and Technology·Nitin MehtaR S Dabur
Jul 30, 2016·Critical Reviews in Food Science and Nutrition·Ran YinRui Hai Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.