Whole mitochondrial DNA sequencing in Alpine populations and the genetic history of the Neolithic Tyrolean Iceman

Scientific Reports
Valentina CoiaAlbert Zink

Abstract

The Tyrolean Iceman is an extraordinarily well-preserved natural mummy that lived south of the Alpine ridge ~5,200 years before present (ybp), during the Copper Age. Despite studies that have investigated his genetic profile, the relation of the Iceman´s maternal lineage with present-day mitochondrial variation remains elusive. Studies of the Iceman have shown that his mitochondrial DNA (mtDNA) belongs to a novel lineage of haplogroup K1 (K1f) not found in extant populations. We analyzed the complete mtDNA sequences of 42 haplogroup K bearing individuals from populations of the Eastern Italian Alps - putatively in genetic continuity with the Tyrolean Iceman-and compared his mitogenome with a large dataset of worldwide K1 sequences. Our results allow a re-definition of the K1 phylogeny, and indicate that the K1f haplogroup is absent or rare in present-day populations. We suggest that mtDNA Iceman´s lineage could have disappeared during demographic events starting in Europe from ~5,000 ybp. Based on the comparison of our results with published data, we propose a scenario that could explain the apparent contrast between the phylogeographic features of maternal and paternal lineages of the Tyrolean Iceman within the context of the ...Continue Reading

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Citations

Jan 7, 2017·Scientific Reports·Daniel E PlattPierre A Zalloua
Sep 17, 2019·Bioinformatics and Biology Insights·Koji IshiyaShintaroh Ueda
Sep 11, 2019·Gerontology·Albert R Zink, Frank Maixner

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Datasets Mentioned

BETA
KT749793
KT749816

Software Mentioned

PhyloTree
mtPhyl
house
PAML
Phylotree Build
Haplogrep
Bayesian Evolutionary Analysis Sampling Trees ( BEAST )
BEAST

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