Whole snake venoms: Cytotoxic, anti-metastatic and antiangiogenic properties

Toxicon : Official Journal of the International Society on Toxinology
Harald KerkkampDaniëlle Vlecken

Abstract

Currently, biological and organic substances are screened in order to find a new generation of therapeutics active against cancer. Previous research has identified promising candidate peptides in snake venom. In this study, venoms from different snake species (Naja annulifera, Naja kaouthia, Ophiophagus hannah and Echis carinatus) were screened for potential anti-cancer properties using pancreatic tumour cells as the assay system. The cells were incubated with venom and then subjected to the following analyses: (i) in vitro cell death (ii) in vitro migration (iii) in vivo dissemination and (iv) in vivo angiogenesis. For the in vivo assays, the cells, after incubation and labelling, were transplanted into the yolk sac of zebrafish embryos for motility and angiogenesis. The results showed strong effects in cells treated with venoms from Ophiophagus hannah and Echis carinatus in the in vitro assays. In the in vivo assays, venom derived from Ophiophagus hannah had the most potent effects with respect to angiogenesis. These venoms might therefore be considered as candidates for further studies.

Citations

Sep 29, 2019·Toxins·Tarek Mohamed Abd El-AzizJames D Stockand
Apr 25, 2020·Toxins·Clara Pérez-PeinadoDavid Andreu
Sep 27, 2019·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Benyamin ShahbaziMasoumeh Bagheri
Feb 6, 2019·Toxins·Syafiq Asnawi Zainal AbidinRakesh Naidu
Jan 7, 2021·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Francisc BodaKrisztian Kvell
Dec 5, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Sepideh MirzaeiManoj Garg
Mar 17, 2020·Toxicon : Official Journal of the International Society on Toxinology·Syeda U HashmiSyed A Ali
Jul 20, 2020·Toxicon : Official Journal of the International Society on Toxinology·Danielle McCulloughCarol M Trim
Sep 3, 2021·Toxicon: X·Mitchel Otieno OkumuMercy Seroney Jepkorir

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