Whole, submandibular, and parotid saliva-mediated aggregation of Pseudomonas aeruginosa in cystic fibrosis.

Infection and Immunity
K KomiyamaS K Tumber

Abstract

The aggregation of mucoid and nonmucoid Pseudomonas aeruginosa by submandibular, parotid, and whole saliva from patients with cystic fibrosis (CF) and non-CF subjects was investigated. There were significant differences (P less than 0.01) in aggregation of mucoid and nonmucoid variants of P. aeruginosa by submandibular and whole saliva from CF patients and non-CF subjects. However, the differences in the parotid secretion were not as pronounced. Patients with CF who were colonized with P. aeruginosa demonstrated a significantly higher (P less than 0.05) percent aggregation of the mucoid variants by the submandibular secretion and of both mucoid and nonmucoid variants by whole saliva, compared with corresponding secretions from patients with CF not colonized with this pathogen. The parotid saliva aggregation activity was not markedly different for the two groups with CF. From patients with CF, whole saliva demonstrated a higher percent P. aeruginosa aggregation than did the submandibular saliva. In non-CF subjects, however, the percent aggregation of P. aeruginosa by submandibular saliva was higher than that by whole saliva. Our results indicate that the sero-mucous products of the submandibular gland have a more significant rol...Continue Reading

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Citations

Aug 1, 1992·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·S K Tumber-SainiK Komiyama
Nov 1, 1995·Clinical and Experimental Immunology·D C TaylorR L Clancy
Sep 1, 1993·American Journal of Respiratory Cell and Molecular Biology·C CarnoyP Roussel
May 1, 1993·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·E A ArmstrongK Komiyama
Oct 1, 1996·American Journal of Respiratory and Critical Care Medicine·A ScharfmanP Roussel
Feb 14, 2013·Infection and Immunity·Seok-Mo HeoStefan Ruhl
Sep 20, 1993·Annals of the New York Academy of Sciences·P C Fox
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Oct 1, 1991·Infection and Immunity·A R BiesbrockM J Levine

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