Whole Transcriptome Analysis of Mesenchyme Tissue in Sika Deer Antler Revealed the CeRNAs Regulatory Network Associated With Antler Development

Frontiers in Genetics
Ruobing HanHeping Li

Abstract

Deer antler is the only completely regenerable organ in mammals. During the rapid growth period, the antler proliferates even faster than cancerous tissue growth. However, the proliferation and development of antler have been in a stable and controllable growth cycle. In this study, we analyzed the time series expression data of nine samples from mesenchyme layer in three male sika deer in the early period of the antler with a saddle-like appearance (30 days), the rapid growth period of the antler with two branches (60 days), and the final period of the antler with three branches (90 days). Whole Transcriptome sequencing results show that in the 30 d versus 60 d group, 1,464 genes, 85 long noncoding RNAs (lncRNAs), and 61 miRNAs were identified as differentially expressed; 1,748 genes, 138 lncRNAs, and 78 miRNAs were identified as differentially expressed in 30d versus 90d group; and 816 differentially expressed genes (DEGs), 49 differentially expressed lncRNAs (DE lncRNAs), and 24 differentially expressed miRNA (DE miRNAs) were identified in 60d versus 90d group. A total of 182 miRNA-mRNA interaction pairs and 89 miRNA-lncRNA interaction pairs were screened from DEGs, DE miRNAs, and DE lncRNAs to construct the ceRNA regulatory...Continue Reading

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Citations

Mar 27, 2021·Journal of Proteome Research·Zhen Dong, Dawn Coates
May 20, 2021·The Journal of Steroid Biochemistry and Molecular Biology·Jinmeng YangWuzi Dong

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Datasets Mentioned

BETA
PRJNA552211
PRJNA552158

Methods Mentioned

BETA
RNA-seq
PCR

Software Mentioned

TargetScan
light
CeRNET
DIVID
Tophat2
RNAhybrid
Cytoscape
Miranda
svm

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