Whole-Volume Tumor MRI Radiomics for Prognostic Modeling in Endometrial Cancer.

Journal of Magnetic Resonance Imaging : JMRI
Kristine E FasmerIngfrid H S Haldorsen

Abstract

In endometrial cancer (EC), preoperative pelvic MRI is recommended for local staging, while final tumor stage and grade are established by surgery and pathology. MRI-based radiomic tumor profiling may aid in preoperative risk-stratification and support clinical treatment decisions in EC. To develop MRI-based whole-volume tumor radiomic signatures for prediction of aggressive EC disease. Retrospective. A total of 138 women with histologically confirmed EC, divided into training (nT = 108) and validation cohorts (nV = 30). Axial oblique T1 -weighted gradient echo volumetric interpolated breath-hold examination (VIBE) at 1.5T (71/138 patients) and DIXON VIBE at 3T (67/138 patients) at 2 minutes postcontrast injection. Primary tumors were manually segmented by two radiologists with 4 and 8 years' of experience. Radiomic tumor features were computed and used for prediction of surgicopathologically-verified deep (≥50%) myometrial invasion (DMI), lymph node metastases (LNM), advanced stage (FIGO III + IV), nonendometrioid (NE) histology, and high-grade endometrioid tumors (E3). Corresponding analyses were also conducted using radiomics extracted from the axial oblique image slice depicting the largest tumor area. Logistic least absolu...Continue Reading

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Citations

Dec 4, 2020·Journal of Magnetic Resonance Imaging : JMRI·Michael Torkzad
Jul 24, 2021·Abdominal Radiology·Cibele LunaFrancesco Alessandrino

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Methods Mentioned

BETA
biopsy
hysterectomy
dissection
feature extraction

Software Mentioned

ITK
LASSO
STATA
Enet regression
SNAP
Enet

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