PMID: 20626346Jul 16, 2010Paper

Why and how we should treat elderly patients with hypertension?

Current Vascular Pharmacology
W S Aronow

Abstract

Double-blind, randomized, placebo-controlled studies have documented that antihypertensive drug therapy decreases cardiovascular events in older persons. In the Hypertension in the Very Elderly Trial, patients aged 80 years and older treated with antihypertensive drug therapy had at 1.8-year follow-up, a 30% insignificant decrease in fatal or nonfatal stroke, a 39% significant decrease in fatal stroke, a 21% significant decrease in all-cause mortality, a 23% insignificant decrease in death from cardiovascular causes, and a 64% significant decrease in heart failure. The goal of treatment of hypertension in older persons is to decrease the blood pressure to < 140/90 mm Hg and to <130/80 mm Hg in older persons with diabetes or chronic renal disease. Elderly persons with diastolic hypertension should have their diastolic blood pressure reduced to 80 to 85 mm Hg. There are no randomized controlled clinical trials supporting a target blood pressure of less than 130/80 mm Hg in elderly persons. The optimum diastolic blood pressure goal in elderly persons is unclear. Diuretics should be used as initial therapy in persons with no associated medical conditions. The selection of antihypertensive drug therapy in persons with associated med...Continue Reading

Citations

May 21, 2011·Family Practice·M S PaulsenM Andersen
Jul 14, 2018·Expert Review of Clinical Pharmacology·Ashish CorreaWilbert S Aronow
Oct 28, 2010·Expert Opinion on Pharmacotherapy·Maciej Banach, Jacek Rysz
Mar 12, 2017·Aging & Mental Health·Offer E EdelsteinYaacov G Bachner

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