PMID: 8600971Mar 15, 1996Paper

Why and when channelling can decrease pool size at constant net flux in a simple dynamic channel

Biochimica Et Biophysica Acta
P MendesH V Westerhoff

Abstract

Cornish-Bowden and Cárdenas (Cornish-Bowden, A. and Cárdenas M.L. (1993) Eur. J. Biochem. 213, 87-92) have suggested that simulation results peviously published by us (Mendes, P., Kell, D.B. and Westerhoff, H.V. (1992) Eur. J. Biochem. 204, 255-266) which had demonstrated that large reductions of intermediate pool sizes could be accompanied by increasing channel flux in a model metabolic pathway, were an artefact of changes in the pathway's overall flux of the order of 0.0075%, or of inappropriate alterations of enzyme activities. They also asserted to prove that the "channelling of an intermediate cannot affect its free concentration at constant net flux". We consider the co-response of the intermediate metabolite concentration ('pool') and the channel flux to changes in kinetic (or thermodynamic) parameters. Both by analytical proofs and by numerical examples we show that this co-response can be positive, negative or null, depending on the parameter change. In particular, we prove that there is always a number of ways of changing parameters such that the intermediate metabolite concentration decreases with increasing channel flux, whether the total flux varies or is constant. We also show that increased stability of the (dyna...Continue Reading

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Citations

Sep 27, 2006·Pituitary·Joseph E Ippolito
Jul 2, 2004·Nature Reviews. Cancer·Julian L Griffin, John P Shockcor
Jun 15, 2005·Nature Reviews. Microbiology·Douglas B KellStephen G Oliver
Jan 17, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jennifer L SpratlinS Gail Eckhardt
Oct 15, 2013·The Journal of Chemical Physics·Alexander BuchnerUlrich Gerland
Aug 30, 2013·BioMed Research International·Diego F Gomez-CasatiMaría V Busi
Jul 1, 1996·FEBS Letters·B N KholodenkoM Cascante
Jun 17, 2008·Journal of Cellular and Molecular Medicine·Ignasi BarbaDavid Pozo
Apr 15, 2016·Journal of the Royal Society, Interface·Fei HeHans V Westerhoff
Jun 12, 2014·Journal of Neuropathology and Experimental Neurology·Mariona JovéReinald Pamplona
Dec 6, 2014·Molecular and Biochemical Parasitology·Jurgen R HaanstraPaul A M Michels
Sep 10, 2011·Journal of Proteome Research·Patrizia BerniniAdriana Tognaccini
Jul 11, 2007·Expert Review of Molecular Diagnostics·Douglas B Kell
Mar 6, 1999·Nature·D B Kell
Sep 22, 2006·Systems Biology·A E C IhekwabaD B Kell
Feb 1, 1997·Pediatric Annals·G A Carter
Feb 25, 2017·PloS One·Liubov PoshyvailoSvyatoslav Kondrat
Nov 20, 2015·The American Journal of Clinical Nutrition·Ewa GralkaBernd Schultes
Jan 27, 2019·Scientific Reports·Andrij KuzmakSvyatoslav Kondrat
May 17, 2013·Physical Review Letters·Alexander BuchnerUlrich Gerland
Dec 17, 2008·Journal of Proteome Research·Ivano BertiniLeonardo Tenori
Sep 22, 2021·Molecular Cell·Vidhi PareekStephen J Benkovic

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