Why are hematopoietic stem cells so 'sexy'? on a search for developmental explanation

Leukemia
Mariusz Z Ratajczak

Abstract

Evidence has accumulated that normal human and murine hematopoietic stem cells express several functional pituitary and gonadal sex hormones, and that, in fact, some sex hormones, such as androgens, have been employed for many years to stimulate hematopoiesis in patients with bone marrow aplasia. Interestingly, sex hormone receptors are also expressed by leukemic cell lines and blasts. In this review, I will discuss the emerging question of why hematopoietic cells express these receptors. A tempting hypothetical explanation for this phenomenon is that hematopoietic stem cells are related to subpopulation of migrating primordial germ cells. To support of this notion, the anatomical sites of origin of primitive and definitive hematopoiesis during embryonic development are tightly connected with the migratory route of primordial germ cells: from the proximal epiblast to the extraembryonic endoderm at the bottom of the yolk sac and then back to the embryo proper via the primitive streak to the aorta-gonado-mesonephros (AGM) region on the way to the genital ridges. The migration of these cells overlaps with the emergence of primitive hematopoiesis in the blood islands at the bottom of the yolk sac, and definitive hematopoiesis that ...Continue Reading

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Citations

Nov 24, 2017·The Indian Journal of Medical Research·Deepa Bhartiya
Nov 18, 2017·Reproductive Biology and Endocrinology : RB&E·Deepa BhartiyaSeema Parte
Jul 28, 2018·Stem Cells and Development·Deepa BhartiyaPushpa Singh
Jan 18, 2019·Circulation Research·Mariusz Z RatajczakMagda Kucia
Jan 8, 2019·Journal of American College Health : J of ACH·Shelly R Hovick, Nathan Silver
Oct 3, 2020·Annals of Hematology·Francesca PalandriLucia Catani
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Apr 10, 2021·Journal of the American Chemical Society·Haw-Young KwonYoung-Tae Chang
May 27, 2021·Reproductive Sciences·Xiangping LiChunhua Deng

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