PMID: 22329298Feb 15, 2012Paper

Why chlorthalidone, the thiazide antihypertensive of choice, is neglected?

Lijec̆nic̆ki vjesnik
Zvonko Rumboldt

Abstract

Diuretics, particularly thiazides and thiazide-like drugs, are antihypertensives of first choice. A prominent role in this group is reserved to chlorthalidone because of several pharmacological (e.g. longer biological half-life) and clinical advantages (e.g. superior reduction in cardiovascular events). Nevertheless, favored is hydrochlorothiazide, especially in fixed drug combinations, revealing a poor policy.

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