PMID: 2488084Jan 1, 1989Paper

Why different trials on digitalis give conflicting data

Cardiovascular Drugs and Therapy
R Jaeschke, G H Guyatt

Abstract

Taking a careful look at each of the outcomes measured in randomized, controlled trials of digoxin suggest that discrepancies in results may be more apparent than real. Digoxin does work, but clinically important benefit is restricted to a relatively small proportion of congestive heart failure (CHF) patients. The play of chance, the dose of digoxin used, and the severity of heart failure in patients enrolled in the studies are other factors that may explain the variability in results that were observed. A systematic examination of the sort undertaken here is likely to help resolve apparent difference in outcomes of clinical trials of new (and old) therapies in CHF patients.

References

Feb 1, 1988·The American Journal of Cardiology·G H GuyattD W Taylor
Jul 1, 1988·Annals of Internal Medicine·P R MarantzJ N Tobin
Jan 1, 1985·Journal of Chronic Diseases·B Kirshner, G Guyatt
Jan 1, 1985·Journal of Chronic Diseases·G H Guyatt
Mar 1, 1983·Journal of Cardiovascular Pharmacology·A J TaggartD G McDevitt
Mar 25, 1982·The New England Journal of Medicine·D C LeeE Haber

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Citations

Jun 4, 1992·The American Journal of Cardiology·M Gheorghiade, B J Zarowitz
Jul 6, 2020·Mechanisms of Ageing and Development·Christopher Boulton, J Mark Wilkinson

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