Why do cone photoreceptors die in rod-specific forms of retinal degenerations?

Ophthalmic Genetics
Robert K Koenekoop

Abstract

Retinal degenerations such as retinitis pigmentosa (RP) lead to rod death due to apoptotic cell death, initiated by mutations in retinal genes that encode proteins with crucial photoreceptors functions. The mechanism(s) of cone death have remained elusive until this study. Using a combination of animal models of human RP, Affymetrix expression array studies, RT-PCR and immunohistochemical analyses, Punzo et al. determined that cone death is due to nutritional deficiencies, starration, and autophagy driven by the insulin/mTOR pathway. These novel and exciting seights also provide alternative avenues for therapeutic interventions for cone rescue.

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Citations

Oct 14, 2011·Gene Therapy·V BusskampB Roska
Feb 12, 2011·Ophthalmology·Muhammad Imran KhanAnneke I den Hollander
Jun 12, 2013·Veterinary Ophthalmology·Caroline J Zeiss
Oct 10, 2013·Biologie aujourd'hui·Botond RoskaSerge Picaud
Jul 12, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Yuko EmotoAiro Tsubura
Dec 23, 2015·Retina·Satoko NakagawaNagahisa Yoshimura

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