PMID: 9440553Jan 24, 1998Paper

Why do defects in the Fas-Fas ligand system cause autoimmunity?

The Journal of Allergy and Clinical Immunology
T Suda, S Nagata

Abstract

We have previously isolated genes that encode Fas and Fas ligand, a receptor-ligand pair that mediates an apoptotic signal. We also have demonstrated that lpr and gld mice, well-known animal models of autoimmune disease are loss-of-function mutants of the Fas and Fas ligand genes, respectively. Patients with autoimmune lymphoproliferative disorders have been found to bear mutations of the Fas gene. These findings indicate that the Fas-Fas ligand system plays an important role in the maintenance of self-tolerance among both humans and mice. During T-cell development, mouse T cells initially express Fas in the thymus and maintain their expression thereafter. Peripheral B cells usually express Fas at much lower levels than do T cells, but various stimuli enhance Fas expression on B cells. In contrast, among the lymphocyte subsets, only activated T cells and natural killer cells express readily detectable levels of Fas ligand. Reactivation of previously activated T cells through T-cell receptors induces apoptosis. This phenomenon (activation-induced cell death) is mediated by means of the Fas-Fas ligand interaction. We recently discovered that peripheral naive T cells in mice are susceptible to Fas ligand but not to agonistic anti-...Continue Reading

Citations

Aug 6, 2002·Toxicology·Loren D KollerMaria V Ruiz Mendez
Oct 16, 2013·Molecular Therapy : the Journal of the American Society of Gene Therapy·Susan M FaustJames M Wilson
Jul 10, 2004·Thyroid : Official Journal of the American Thyroid Association·Hayato MaruokaYoshinori Iwatani
Jun 10, 2010·Journal of Aerosol Medicine and Pulmonary Drug Delivery·Nancy Gordon, Eugenie S Kleinerman
Aug 27, 2009·Arthritis Research & Therapy·Steven K Lundy, David A Fox
Jul 6, 2014·International Immunology·Kazuhito HonjoHiromi Kubagawa
Feb 13, 2016·Proceedings of the National Academy of Sciences of the United States of America·Kazuyuki AkaneHaruhiko Suzuki
Jan 24, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Wen-Tsong HsiehJing-Gung Chung
Apr 9, 2015·Frontiers in Immunology·Steven K LundyDavid A Fox
Mar 4, 2011·International Journal of Hygiene and Environmental Health·Qing ChenQingbin Zhang
Mar 1, 2008·Expert Review of Clinical Immunology·Inka Brockhausen, Tassos P Anastassiades
May 9, 2002·Cornea·Yoichiro Sano, Chie Sotozono
Apr 21, 2017·Frontiers in Immunology·Akiko YamadaNaozumi Ishimaru
Sep 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·M L Santiago-RaberA N Theofilopoulos
Jul 7, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J WangP B Ernst
Aug 7, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Masayuki FukuiTakashi Suda
Jan 13, 2005·International Journal of Cancer. Journal International Du Cancer·Yin LiRobert L Fine
Jul 6, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M SatohW H Reeves
Nov 8, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Claire GoulvestreFrédéric Batteux
Dec 29, 2020·Life Science Alliance·André F RendeiroGiorgio Inghirami

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