Why do patients decline amniocentesis? Analysis of factors influencing the decision to refuse invasive prenatal testing

BMC Pregnancy and Childbirth
Pawel SadleckiMalgorzata Walentowicz-Sadlecka

Abstract

In recent years, determination of personalized risk for fetal chromosomal anomalies emerged as an important component of prenatal genetic counseling. Women in whom fetal risk for chromosomal aberrations is elevated are offered further testing. The aim of this study was to identify factors that may influence the decision to refuse invasive prenatal testing aimed at determination of fetal karyotype in a group of patients at increased risk of trisomy 21. The analysis included 177 patients with singleton pregnancy, whose personalized risk score for trisomy 21 calculated on the basis of the combined test exceeded 1:300. Diagnostic amniocentesis was performed in 125 patients from this subset, since the remaining 52 women declined invasive prenatal testing. The following factors were analyzed as potential determinants of the decision to refuse amniocentesis: maternal age (≥35 years), gravidity, number of miscarriages in previous pregnancies, educational status, marital status, indications to prenatal testing, gestational age at the time of prenatal testing, personalized risk score for fetal chromosomal aberrations and nuchal translucency (NT) value. A statistically significant relationship was found between the decision to refuse amni...Continue Reading

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Citations

Jan 1, 2021·American Journal of Medical Genetics. Part a·Meaghann S WeaverNicole D Birge

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Methods Mentioned

BETA
chromosomal aberrations
chromosomal aberration

Software Mentioned

PQStat

Related Concepts

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