Abstract
In recent years, determination of personalized risk for fetal chromosomal anomalies emerged as an important component of prenatal genetic counseling. Women in whom fetal risk for chromosomal aberrations is elevated are offered further testing. The aim of this study was to identify factors that may influence the decision to refuse invasive prenatal testing aimed at determination of fetal karyotype in a group of patients at increased risk of trisomy 21. The analysis included 177 patients with singleton pregnancy, whose personalized risk score for trisomy 21 calculated on the basis of the combined test exceeded 1:300. Diagnostic amniocentesis was performed in 125 patients from this subset, since the remaining 52 women declined invasive prenatal testing. The following factors were analyzed as potential determinants of the decision to refuse amniocentesis: maternal age (≥35 years), gravidity, number of miscarriages in previous pregnancies, educational status, marital status, indications to prenatal testing, gestational age at the time of prenatal testing, personalized risk score for fetal chromosomal aberrations and nuchal translucency (NT) value. A statistically significant relationship was found between the decision to refuse amni...Continue Reading
References
Aug 26, 1998·Lancet·R J SnijdersK H Nicolaides
Jan 22, 2005·Prenatal Diagnosis·Matthijs van den BergGerrit van der Wal
Feb 8, 2005·Human Reproduction·Guido RagniAnna Elisa Nicolosi
Dec 15, 2005·Prenatal Diagnosis·Marijke J KorenrompGerard H A Visser
Jan 18, 2007·Medical Anthropology Quarterly·Tsipy Ivry
Feb 3, 2007·Taiwanese Journal of Obstetrics & Gynecology·Jenn-Jhy TsengEsther Shih-Chu Ho
Jun 21, 2007·Health Care for Women International·Marian Nicol
Jul 6, 2007·Journal of Perinatology : Official Journal of the California Perinatal Association·S Sharda, S R Phadke
Mar 4, 2008·Obstetrics and Gynecology·Anthony O OdiboJames P Crane
Mar 3, 2009·Midwifery·Heather Skirton, Owen Barr
Oct 31, 2012·American Journal of Obstetrics and Gynecology·Kypros H NicolaidesGisele Touzet
Feb 12, 2013·Journal of Psychosomatic Obstetrics and Gynaecology·Judith L M McCoyd
Apr 6, 2013·Genetics in Medicine : Official Journal of the American College of Medical Genetics·Anthony R GreggM S Watson
Apr 25, 2013·Prenatal Diagnosis·K H NicolaidesD Markova
Sep 24, 2014·JAMA : the Journal of the American Medical Association·Miriam KuppermannMary E Norton
Apr 18, 2015·BMC Pregnancy and Childbirth·Frenny ShethJayesh Sheth
Dec 10, 2015·Pakistan Journal of Medical Sciences·Cem Yasar SanhalSelen Bozkurt
Jan 14, 2016·Molecular Cytogenetics·Ting WangLili Zhang
May 29, 2016·Clinics in Laboratory Medicine·Renée L Chard, Mary E Norton
Oct 21, 2016·Prenatal Diagnosis·Miyuki NishiyamaHaruhiko Sago
Oct 30, 2016·American Journal of Obstetrics and Gynecology·Mary E Norton, Miriam Kuppermann
Mar 16, 2017·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Kristine JohnsonLisa Hui