PMID: 19142362Jan 15, 2009Paper

Why do patients with chagasic cardiomyopathy have worse outcomes than those with non-chagasic cardiomyopathy?

Arquivos brasileiros de cardiologia
Christiano Pereira SilvaAntonio Carlos Pereira Barretto

Abstract

Heart failure is a highly prevalent disease, the prognosis of which depends on different predictive factors. Chagas disease is a predictor of poor prognosis in patients with chronic heart failure (HF). The purpose of this study is to investigate whether this condition also predicts poor outcome in acutely decompensated patients. Four hundred and seventeen patients admitted for decompensated heart failure were studied. Mean age was 51.8 years, and 291 (69.8%) were male. They were divided into two groups: 133 (31.9%) patients with Chagas heart disease (CH) and 284 patients with heart failure of other etiologies. Cytokine and norepinephrine plasma levels were measured in a subgroup of 63 patients (15.1% with Chagas disease). At admission, 24.6% of the patients needed inotropic support, and one-year mortality was 54.7%. Mortality rates were higher in the CH group (69.2% vs. 47.9%, p < 0.001). When data were compared, patients with Chagas disease were younger (47.6 vs. 53.8 years, p < 0.001) and, on average, showed lower systolic blood pressure (96.7 vs. 111.2 mmHg, p < 0,001), ejection fraction (32.7 vs. 36.4%, p < 0.001), and serum Na (134.6 vs. 136.0, p = 0.026), in addition to higher TNF-alpha levels (33.3 vs. 14.8, p = 0.001). ...Continue Reading

Citations

Feb 23, 2017·Revista da Associação Médica Brasileira·Luiza Nauane Borges Azevedo Dos SantosConstança Margarida Sampaio Cruz

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