Why Do Patients with Chronic Inflammatory Rheumatic Diseases Discontinue Their Biologics? An Assessment of Patients' Adherence Using a Self-report Questionnaire

The Journal of Rheumatology
Anne-Laure BetegnieBenoît Allenet

Abstract

Concerns have been raised about nonadherence behavior among patients with chronic inflammatory rheumatic diseases (CIRD) receiving biologics. This nonadherence may be caused by various factors. The main objective was to explain why patients discontinue their biologics of their own accord. A quantitative and descriptive study was performed using a self-report questionnaire that was sent through the Internet to members of different patient associations. Sociodemographic data, medical and therapeutic history, management of biologic administration, previous experiences, and patients' beliefs and perceptions about treatment efficacy and side effects were studied to explain self-discontinuation (SD). A total of 581 patients answered the questionnaire between June 16, 2012, and July 4, 2012, including patients with ankylosing spondylitis (351/581, 60.4%), rheumatoid arthritis (196/581, 33.7%), psoriatic arthritis (30/581, 5.2%), and other CIRD (4/581, 0.7%). More than 1000 different biologics were described by the 581 patients, with a median of 2 lines per patient. Eighty-six patients discontinued their biologics of their own accord (14.8%). In a multivariate analysis, factors that were significantly related to SD were low level of pa...Continue Reading

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Citations

May 10, 2017·Therapeutic Drug Monitoring·Gilles PaintaudDenis Mulleman
Oct 10, 2018·Therapeutic Drug Monitoring·Erwin Dreesen, Ann Gils
Apr 3, 2019·The Journal of Rheumatology·Teresa SemaluluMaggie J Larché
Feb 17, 2019·The Journal of Rheumatology·M Garrido-CumbreraUNKNOWN Atlas working group
Nov 30, 2016·Clinical Rheumatology·Aleksander Lenert, Petar Lenert
Mar 19, 2019·Therapeutic Drug Monitoring·Erwin Dreesen, Ann Gils
Sep 19, 2017·Current Rheumatology Reports·Natasha K J CampbellMary A De Vera
Feb 26, 2019·Joint, Bone, Spine : Revue Du Rhumatisme·Catherine Beauvais
Jun 19, 2021·Revue des maladies respiratoires·S Ottaviani, M Forien
Oct 28, 2021·Rheumatology International·Chiara GasteigerNicola Dalbeth

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