Why do people die from pulmonary sarcoidosis?

Current Opinion in Pulmonary Medicine
Vasileios KouranosSimon L F Walsh

Abstract

In sarcoidosis, the design and validation of an appropriate risk stratification strategy is hampered by the considerable variability in initial presentation, disease evolution, and outcome. Although spontaneous resolution of the disease is described in a large proportion of patients, approximately 20-30% would present with chronic or progressive lung disease that has been associated with morbidity and mortality. Higher morbidity and mortality can be related to both the disease severity and extent as well as its treatments. We review the utility of integration of clinical, pathological, and radiological features of pulmonary sarcoidosis to detect pulmonary sarcoidosis patient at risk of developing severe, fibrotic lung disease. Recently published studies suggested a mortality rate of 11-14 per 1000 person-years. Demographic characteristics such as age, sex, and race may play a role but conflicting evidence are reported depending on the origin of the population. To date, there are no tools that can reliably predict the exact group of pulmonary sarcoidosis patients to progress to fibrosis. Imaging contributes significantly to the diagnosis and management of patients with sarcoidosis as it can provide useful information regarding t...Continue Reading

References

Feb 1, 1992·Radiology·M W BraunerD Valeyre
Apr 1, 1974·American Journal of Epidemiology·P E Sartwell, L B Edwards
Jun 1, 1997·AJR. American Journal of Roentgenology·Z C TraillF V Gleeson
Dec 31, 1997·American Journal of Respiratory and Critical Care Medicine·M W ZiegenhagenJ Müller-Quernheim
Jun 14, 2000·AJR. American Journal of Roentgenology·M AbehseraM W Brauner
Feb 11, 2003·Chest·Marc A JudsonUNKNOWN ACCESS Research Group
Mar 29, 2003·The European Respiratory Journal·M W ZiegenhagenJ Müller-Quernheim
Jun 5, 2003·European Radiology·Susan J Buckingham, David M Hansell
Dec 6, 2003·American Journal of Respiratory and Critical Care Medicine·Johan GrunewaldOlle Olerup
Sep 28, 2004·European Radiology·Anne-Sophie HennebicqueMichel W Brauner
Jan 18, 2005·Chest·Masanori AkiraMitsunori Sakatani
Aug 2, 2006·Clinics in Chest Medicine·Gloria E Westney, Marc A Judson
Oct 26, 2007·The European Respiratory Journal·T MorimotoT Nukiwa
Nov 23, 2007·The New England Journal of Medicine·Michael C IannuzziAlvin S Teirstein
Mar 5, 2009·European Journal of Nuclear Medicine and Molecular Imaging·Ruth G KeijsersJan C Grutters
Aug 15, 2009·The European Respiratory Journal·H SatoK I Welsh
Jul 3, 2010·The European Respiratory Journal·N L Smith, D W Denning
Jul 21, 2010·Journal of Neurology·M BakkersI S J Merkies
Jan 11, 2011·Tissue Antigens·M HeronJ M M van den Bosch
Jan 25, 2011·Human Immunology·Petal A WijnenMarjolein Drent
Feb 19, 2011·American Journal of Respiratory and Critical Care Medicine·Jeffrey J SwigrisKevin K Brown
Jun 30, 2011·Lung India : Official Organ of Indian Chest Society·Rajendra PrasadShilpi Karmakar
Jun 30, 2011·Lung India : Official Organ of Indian Chest Society·Laleng M Darlong
Nov 15, 2011·The European Respiratory Journal·A NardiH Nunes
Jun 30, 2012·The European Respiratory Journal·David W DenningDonald C Cole
Jul 14, 2012·The European Respiratory Journal·Hilario NunesPierre-Yves Brillet
Mar 30, 2013·Chest·Adriane D M VorselaarsJan C Grutters
Feb 8, 2014·The Lancet. Respiratory Medicine·Simon Lf WalshDavid M Hansell
Jul 22, 2014·Current Opinion in Pulmonary Medicine·Adriane D M VorselaarsMarjolein Drent
Jul 22, 2014·Current Opinion in Pulmonary Medicine·Dominique ValeyreJean-François Bernaudin
Sep 5, 2014·Chest·Mehdi MirsaeidiRobert P Baughman

❮ Previous
Next ❯

Citations

Aug 3, 2020·Current Opinion in Pulmonary Medicine·Divya C Patel, Dominique Valeyre
Nov 7, 2019·ERJ Open Research·Nynke A KampstraJan C Grutters

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Clinics in Chest Medicine
Vasileios KouranosA Wells
European Radiology
Paolo SpagnoloDavid M Hansell
© 2022 Meta ULC. All rights reserved