Why Do Schwann Cells Survive in the Absence of Axons?

Annals of the New York Academy of Sciences
K R Jessen, R Mirsky

Abstract

Schwann cell precursors in embryonic nerves rely for survival on signals from the axons they associate with. A major component of this signal is β neuregulin. While it can be argued that such paracrine axonal regulation makes biological sense in embryonic nerves, such an arrangement would be problematic postnatally, since nerve damage would then lead to Schwann cell death with adverse consequences for regeneration; in fact, transection of older nerves is not accompanied by a detectable increase in Schwann cell death. Our evidence indicates that this is, at least in part, due to the ability of Schwann cells to support their own survival by autocrine circuits. These circuits are not present in Schwann cell precursors. We have identified insulin-like growth factor, neurotrophin-3 and platelet-derived growth factor-BB as components of the autocrine Schwann cell survival signal.

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Citations

Jul 27, 2005·Journal of Neuropathology and Experimental Neurology·Yuan Yuan ChenDouglas W Zochodne
Jan 14, 2003·The Journal of Biological Chemistry·Yiwen LiGihan I Tennekoon
Nov 21, 2007·Neuropathology : Official Journal of the Japanese Society of Neuropathology·Nobuyuki OkaIchiro Akiguchi
Apr 3, 2001·The Journal of Hand Surgery : Journal of the British Society for Surgery of the Hand·S Hall
Jan 21, 2011·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Jeff Biernaskie, Freda D Miller
Jan 23, 2010·The European Journal of Neuroscience·Philip W SheardMarilyn J Duxson
Sep 1, 2015·Frontiers in Cellular Neuroscience·Esperanza BasAdrien A Eshraghi
Dec 13, 2016·Journal of Tissue Engineering and Regenerative Medicine·Gianluca CarnevaleAnto de Pol
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May 14, 2009·Neurosurgical Focus·Sarah Walsh, Rajiv Midha
Feb 4, 2011·Journal of Neuroscience Research·Yang ShiSteven L Gonias
Jul 30, 2009·Cell and Tissue Research·Yujun WeiXiufang Zhang
Jun 29, 2007·Microsurgery·S GeunaI Perroteau
Aug 10, 2019·Methods : a Companion to Methods in Enzymology·Michael J BuckenmeyerBryan N Brown

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