Why do we think we know what we know? A metaknowledge analysis of the salt controversy

International Journal of Epidemiology
Ludovic TrinquartSandro Galea

Abstract

Although several public health organizations have recommended population-wide reduction in salt intake, the evidence on the population benefits remains unclear. We conducted a metaknowledge analysis of the literature on salt intake and health outcomes. We identified reports--primary studies, systematic reviews, guidelines and comments, letters or reviews--addressing the effect of sodium intake on cerebro-cardiovascular disease or mortality. We classified reports as supportive or contradictory of the hypothesis that salt reduction leads to population benefits, and constructed a network of citations connecting these reports. We tested for citation bias using an exponential random graph model. We also assessed the inclusion of primary studies in systematic reviews on the topic. We identified 269 reports (25% primary studies, 5% systematic reviews, 4% guidelines and 66% comments, letters, or reviews) from between 1978 and 2014. Of these, 54% were supportive of the hypothesis, 33% were contradictory and 13% were inconclusive. Reports were 1.51 [95% confidence interval (CI) 1.38 to 1.65] times more likely to cite reports that drew a similar conclusion, than to cite reports drawing a different conclusion. In all, 48 primary studies we...Continue Reading

References

Jan 8, 1998·The New England Journal of Medicine·H T StelfoxA S Detsky
May 30, 1998·JAMA : the Journal of the American Medical Association·D E Barnes, L A Bero
Aug 29, 1998·Science·G Taubes
Apr 3, 2002·Journal of Clinical Epidemiology·Lise L Kjaergard, Christian Gluud
Aug 11, 2007·Journal of Clinical Epidemiology·Pentti NieminenMartin Schumacher
Jul 25, 2008·Journal of Statistical Software·Martina MorrisDavid R Hunter
Oct 3, 2008·PLoS Medicine·UNKNOWN PLoS Medicine Editors
Jan 9, 2009·Journal of Clinical Epidemiology·Jean-François Etter, John Stapleton
Jul 23, 2009·BMJ : British Medical Journal·Steven A Greenberg
May 1, 2008·Journal of Statistical Software·David R HunterMartina Morris
Jan 12, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·R L Atkinson, I Macdonald
Jan 22, 2010·The New England Journal of Medicine·Kirsten Bibbins-DomingoLee Goldman
Feb 12, 2011·Science·James A Evans, Jacob G Foster
Mar 12, 2011·Journal of Evaluation in Clinical Practice·Steven A Greenberg
Aug 13, 2011·BMJ : British Medical Journal·Francesco P CappuccioKlim McPherson
Sep 29, 2011·BMJ : British Medical Journal·Niels Graudal, Gesche Jürgens
Nov 19, 2011·American Journal of Public Health·David J Rothman
Nov 24, 2011·JAMA : the Journal of the American Medical Association·Martin J O'DonnellRoland E Schmieder
May 26, 2012·American Journal of Hypertension·Michael H Alderman, Hillel W Cohen
Jun 9, 2012·Artificial Intelligence in Medicine·Tanja Bekhuis, Dina Demner-Fushman
Jan 26, 2013·Journal of Clinical Epidemiology·Anne-Sophie JannotThomas V Perneger
Sep 7, 2013·Science·David Merritt JohnsSandro Galea
Feb 12, 2014·Circulation·Laura K CobbUNKNOWN American Heart Association Council on Lifestyle and Metabolic Health
Mar 29, 2014·Environmental Health Perspectives·Kevin C Elliott, David B Resnik
Jul 6, 2014·American Journal of Epidemiology·Mika KivimäkiEric J Brunner
Aug 15, 2014·The New England Journal of Medicine·Dariush MozaffarianUNKNOWN Global Burden of Diseases Nutrition and Chronic Diseases Expert Group
Nov 2, 2014·Environmental Health Perspectives·Kevin C Elliott, David B Resnik
Dec 3, 2014·Journal of Clinical Epidemiology·Xujuan ZhouAdam G Dunn
Dec 4, 2014·Advances in Nutrition·Andrew W BrownDavid B Allison

❮ Previous
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Citations

Feb 19, 2016·International Journal of Epidemiology·John P A Ioannidis
Feb 19, 2016·International Journal of Epidemiology·Martin O'DonnellSalim Yusuf
Jun 2, 2016·The New England Journal of Medicine·Mary E CogswellThomas R Frieden
Nov 8, 2016·International Journal of Epidemiology·Pepita BarlowDavid Stuckler
Jun 13, 2017·Journal of Clinical Epidemiology·Bram DuyxMaurice P Zeegers
Apr 5, 2018·American Journal of Public Health·Sandro Galea
Nov 27, 2018·Public Health Nutrition·Milena Sia PerinMaria-Cecília Bueno Jayme Gallani
Feb 1, 2018·Current Atherosclerosis Reports·Kate J BowenKristina S Petersen
Oct 31, 2019·The New England Journal of Medicine·Stephen P JuraschekShivani Sahni
Aug 24, 2016·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Robert E Tarone
Jan 22, 2020·The British Journal of Nutrition·Micah Leshem
Jan 7, 2020·Advances in Nutrition·Saiuj BhatJason H Y Wu
Jan 1, 2017·International Journal of Epidemiology·Norm Rc Campbell
Nov 10, 2017·Journal of Hypertension·Emmanuelle Vidal-PetiotMartin Flamant
Jan 18, 2018·The Journal of Clinical Hypertension·Aaron LuckoNorm Rc Campbell
May 24, 2019·Annals of the New York Academy of Sciences·Gareth LengStewart Maclean
Jul 6, 2020·Nutrition Reviews·Ghadeer S AljuraibanDorairaj Prabhakaran
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Isabelle Boutron, Philippe Ravaud
Oct 31, 2019·The New England Journal of Medicine·David M JohnsSandro Galea
Oct 17, 2019·Journal of the American Heart Association·Abu Mohd NaserK M Venkat Narayan
Jul 20, 2016·International Journal of Epidemiology·Shah Ebrahim
Aug 2, 2017·Journal of Genetics·Milind Watve
Dec 6, 2020·Journal of Clinical Epidemiology·Miriam J E UrlingsMaurice P Zeegers
Sep 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Gaëlle PetitJean-Luc Martin
Oct 3, 2020·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Shiu Lun Au Yeung, Catherine Mary Schooling
Jan 1, 2020·Proceedings of the Association for Information Science and Technology·Tzu-Kun HsiaoJodi Schneider
Sep 12, 2019··Daniel MeusburgerAlexander Ilic

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