Why does Kluyveromyces lactis not grow under anaerobic conditions? Comparison of essential anaerobic genes of Saccharomyces cerevisiae with the Kluyveromyces lactis genome

FEMS Yeast Research
I S Ishtar Snoek, H Y Steensma

Abstract

Although some yeast species, e.g. Saccharomyces cerevisiae, can grow under anaerobic conditions, Kluyveromyces lactis cannot. In a systematic study, we have determined which S. cerevisiae genes are required for growth without oxygen. This has been done by using the yeast deletion library. Both aerobically essential and nonessential genes have been tested for their necessity for anaerobic growth. Upon comparison of the K. lactis genome with the genes found to be anaerobically important in S. cerevisiae, which yielded 20 genes that are missing in K. lactis, we hypothesize that lack of import of sterols might be one of the more important reasons that K. lactis cannot grow in the absence of oxygen.

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Citations

Aug 29, 2012·Oxidative Medicine and Cellular Longevity·M Isabel González Siso, M Esperanza Cerdán
Oct 3, 2012·BMC Genomics·Oscar DiasIsabel Rocha
Sep 12, 2012·Antonie van Leeuwenhoek·Valdilene Canazart dos SantosFlávia Maria Lopes Passos
Dec 17, 2008·Journal of Proteomics·Astrid BruckmannG Paul H van Heusden
Dec 29, 2006·Yeast·I S Ishtar Snoek, H Yde Steensma
Apr 30, 2014·Biotechnology Journal·Oscar DiasIsabel Rocha
Jun 5, 2016·Applied Microbiology and Biotechnology·Andreas K GombertMaría-Isabel González-Siso
May 19, 2018·The Journal of Biological Chemistry·Diane M WardJames E Cox
Nov 7, 2018·FEMS Microbiology Letters·Alexandra KonecnaYvetta Gbelska
Feb 6, 2018·Applied Microbiology and Biotechnology·Bruno Labate Vale da CostaAndreas Karoly Gombert
Jan 24, 2020·Yeast·Thomas PerliJean-Marc Daran
Apr 25, 2006·FEMS Yeast Research·Albert J J van OoyenChristopher H Taron
Apr 15, 2021·FEMS Yeast Research·Catherine TesnièreJean-Luc Legras
Apr 17, 2021·Applied Microbiology and Biotechnology·María Dolores PendónGraciela L Garrote
Jul 26, 2021·Metabolic Engineering·Wijbrand J C DekkerJack T Pronk

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