Why does the world need another rotavirus vaccine?

Therapeutics and Clinical Risk Management
Richard L WardA Duncan Steele

Abstract

A "Meeting on Upstream Rotavirus Vaccines and Emerging Vaccine Producers" was held at the World Health Organization in Geneva, Switzerland on March 28-30, 2006. The purpose was to discuss, evaluate, and weigh the importance of additional rotavirus vaccine candidates following the successful international licensure of rotavirus vaccines by two major pharmaceutical companies (GlaxoSmithKline and Merck) that had been in development for many years. Both licensed vaccines are composed of live rotaviruses that are delivered orally as have been all candidate rotavirus vaccines evaluated in humans. Each is built on the experience gained with previous candidates whose development had either been discontinued or, in the case of the previously licensed rhesus rotavirus reassortant vaccine (Rotashield), was withdrawn by its manufacturer after the discovery of a rare association with intussusception. Although which alternative candidate vaccines should be supported for development and where this should be done are controversial topics, there was general agreement expressed at the Geneva meeting that further development of alternative candidates is a high priority. This development will help insure that the most safe, effective and economic ...Continue Reading

Citations

Jun 16, 2012·Human Vaccines & Immunotherapeutics·Chiara MameliGian Vincenzo Zuccotti
Oct 1, 2014·Critical Reviews in Microbiology·Zenas Kuate Defo, Byong Lee
Dec 10, 2009·Future Microbiology·Jelle MatthijnssensMarc Van Ranst
Dec 1, 2009·Expert Review of Vaccines·Miguel O'Ryan, Alexandre C Linhares
Aug 3, 2011·Expert Review of Vaccines·Jimmy A Mena, Amine A Kamen
Nov 16, 2013·Archives of Virology·Mabel RodríguezLaura A Palomares
Mar 26, 2010·Electrophoresis·Ricardo M Castro-AcostaLaura A Palomares
Sep 29, 2009·Veterinary Microbiology·V MartellaMax Ciarlet

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Methods Mentioned

BETA
electron microscopy
electron
biopsy
electrophoresis

Software Mentioned

Rotarix
RotaTeq

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