Why harmonization is needed when using FDG PET/CT as a prognosticator: demonstration with EARL-compliant SUV as an independent prognostic factor in lung cancer

European Journal of Nuclear Medicine and Molecular Imaging
Benjamin HouduNicolas Aide

Abstract

To determine EARL-compliant prognostic SUV thresholds in a mature cohort of patients with locally advanced NSCLC, and to demonstrate how detrimental it is to use a threshold determined on an older-generation PET system with a newer PET/CT machine, and vice versa, or to use such a threshold with non-harmonized multicentre pooled data. This was a single-centre retrospective study including 139 consecutive stage IIIA-IIIB patients. PET data were acquired as per the EANM guidelines and reconstructed with unfiltered point spread function (PSF) reconstruction. Subsequently, a 6.3 mm Gaussian filter was applied using the EQ.PET (Siemens Healthineers) methodology to meet the EANM/EARL harmonizing standards (PSFEARL). A multicentre study including non-EARL-compliant systems was simulated by randomly creating four groups of patients whose images were reconstructed with unfiltered PSF and PSF with Gaussian post-filtering of 3, 5, and 10 mm. Identification of optimal SUV thresholds was based on a two-fold cross-validation process that partitioned the overall sample into learning and validation subsamples. Proportional Cox hazards models were used to estimate age-adjusted and multivariable-adjusted hazard ratios (HRs) and their 95% confiden...Continue Reading

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Mar 4, 2018·European Journal of Nuclear Medicine and Molecular Imaging·Andres KaalepRonald Boellaard

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Citations

Nov 23, 2019·European Journal of Nuclear Medicine and Molecular Imaging·Romain-David SebanBenjamin Besse
Mar 10, 2019·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Maria Vittoria MattoliAlessandro Giordano
Oct 22, 2020·Physics in Medicine and Biology·D G KovacsF L Andersen
Apr 24, 2021·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Filippo G Dall'OlioAndrea Ardizzoni
May 16, 2021·European Journal of Nuclear Medicine and Molecular Imaging·Julian M M RogaschCarsten Kobe

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