Why has reversal of the actin-myosin cross-bridge cycle not been observed experimentally?

Journal of Applied Physiology
Denis S LoiselleN A Curtin

Abstract

We trace the history of attempts to determine whether the experimentally observed diminution of metabolic energy expenditure when muscles lengthen during active contraction is consistent with reversibility of biochemical reactions and, in particular, with the regeneration of ATP. We note that this scientific endeavor has something of a parallel flavor to it, with both early and more recent experiments exploiting both isolated muscle preparations and exercising human subjects. In tracing this history from the late 19th century to the present, it becomes clear that energy can be (at least transiently) stored in a muscle undergoing an eccentric contraction but that this is unlikely to be due to the regeneration of ATP. A recently developed, thermodynamically constrained model of the cross-bridge cycle provides additional insight into this conclusion.

References

Apr 10, 1978·Biochimica Et Biophysica Acta·W Hasselbach
Nov 1, 1977·The American Journal of Physiology·G A CavagnaC R Taylor
Sep 1, 1976·The Journal of Physiology·B Bigland-Ritchie, J J Woods
Jun 22, 1976·Pflügers Archiv : European journal of physiology·M Ulbrich, J C Rüegg
Jan 1, 1975·Progress in Biophysics and Molecular Biology·T L Hill
Jan 1, 1974·Progress in Biophysics and Molecular Biology·T L Hill
Nov 1, 1973·Journal of Applied Physiology·B Bigland-RitchieJ J Woods
Feb 28, 1970·Nature·V L LewJ C Ellory
Mar 1, 1968·The Journal of Physiology·D R Wilkie
Jan 1, 1983·Annual Review of Physiology·W Hasselbach, H Oetliker
Feb 1, 1981·Acta Physiologica Scandinavica·C BoscoA Ito
Dec 31, 1997·The Journal of Physiology·J K ConstableC L Gibbs
Jan 30, 1971·FEBS Letters·M Makinose, W Hasselbach
Feb 25, 2003·The Journal of Physiology·Marco LinariN A Curtin
Apr 17, 1953·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·A V HILL
May 28, 1953·The Journal of Physiology·B C ABBOTT, B BIGLAND
Mar 25, 1960·Science·A V HILL
Jun 26, 1964·Science·A A INFANTER E DAVIES
Dec 31, 1951·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B C ABBOTTA V HILL
Dec 31, 1951·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·B C ABBOTT, X M AUBERT
Jul 1, 1952·The Journal of Physiology·B C ABBOTTJ M RITCHIE
May 20, 2006·The Journal of Physiology·W HerzogD E Rassier

❮ Previous
Next ❯

Citations

Nov 22, 2011·Biophysical Journal·Dale C BickhamMichael A Ferenczi
Jul 15, 2016·The Journal of Physiological Sciences : JPS·Kazuhiro Yamada
Aug 1, 2015·Physiological Reports·Kenneth TranEdmund J Crampin
Jan 9, 2013·Journal of Muscle Research and Cell Motility·Marta NocellaBarbara Colombini
May 13, 2015·The Journal of Experimental Biology·Justus O OrtegaKevin E Conley
Sep 4, 2021·Biomechanics and Modeling in Mechanobiology·Christopher J MorrisJames E Moore

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.