Why ice-binding type I antifreeze protein acts as a gas hydrate crystal inhibitor

Physical Chemistry Chemical Physics : PCCP
S Alireza BagherzadehPeter Englezos

Abstract

Antifreeze proteins (AFPs) prevent ice growth by binding to a specific ice plane. Some AFPs have been found to inhibit the formation of gas hydrates which are a serious safety and operational challenge for the oil and gas industry. Molecular dynamics simulations are used to determine the mechanism of action of the winter flounder AFP (wf-AFP) in inhibiting methane hydrate growth. The wf-AFP adsorbs onto the methane hydrate surface via cooperative binding of a set of hydrophobic methyl pendant groups to the empty half-cages at the hydrate/water interface. Each binding set is composed of the methyl side chain of threonine and two alanine residues, four and seven places further down in the sequence of the protein. Understanding the principle of action of AFPs can lead to the rational design of green hydrate inhibitor molecules with potential superior performance.

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Citations

Oct 22, 2015·Biophysical Journal·Tianjun SunVirginia K Walker
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Sep 4, 2015·Journal of the American Chemical Society·Takuma YagasakiHideki Tanaka
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Jan 24, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Tai BuiAlberto Striolo
Apr 25, 2017·Physical Chemistry Chemical Physics : PCCP·Sandipan Chakraborty, Biman Jana
May 16, 2017·Langmuir : the ACS Journal of Surfaces and Colloids·Uday Sankar Midya, Sanjoy Bandyopadhyay
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