Why is start codon selection so precise in eukaryotes?

Translation
Katsura Asano

Abstract

Translation generally initiates with the AUG codon. While initiation at GUG and UUG is permitted in prokaryotes (Archaea and Bacteria), cases of CUG initiation were recently reported in human cells. The varying stringency in translation initiation between eukaryotic and prokaryotic domains largely stems from a fundamental problem for the ribosome in recognizing a codon at the peptidyl-tRNA binding site. Initiation factors specific to each domain of life evolved to confer stringent initiation by the ribosome. The mechanistic basis for high accuracy in eukaryotic initiation is described based on recent findings concerning the role of the multifactor complex (MFC) in this process. Also discussed are whether non-AUG initiation plays any role in translational control and whether start codon accuracy is regulated in eukaryotes.

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Citations

Dec 20, 2015·Trends in Plant Science·Roger P HellensRichard C Macknight
Jan 20, 2015·The Biochemical Journal·Joanna D StewartChristopher G Proud
May 29, 2015·The Arabidopsis Book·Karen S Browning, Julia Bailey-Serres
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Sep 23, 2020·Proceedings of the National Academy of Sciences of the United States of America·Gary LoughranDmitry E Andreev
Mar 24, 2017·Nucleic Acids Research·Ariel HechtMarc Salit
Dec 3, 2020·Nucleic Acids Research·Sylvain de BreyneThéophile Ohlmann
Sep 14, 2018·Biochemistry·Kai Ying LinAssen Marintchev

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Methods Mentioned

BETA
GTPase
nucleotide exchange
FRET
NMR

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