Why is stress so deadly? An evolutionary perspective.

Proceedings. Biological Sciences
Lilach HadanyMarcus W Feldman

Abstract

The reaction of the body to prolonged stress has many harmful effects. Classical theory assumes that stress responses have evolved due to their short-term selective advantages ('flight or fight'), and despite their adverse long-term effects. In contrast, we demonstrate that the adverse effects of stress responses may have a selective advantage. Using an analytical model we show that a gene that causes the early death of a relatively unfit individual can increase in frequency in a structured population even if it has no positive effect on that individual. This result offers a new perspective on the relations between stress factors, stress responses and stress-related diseases.

References

Sep 1, 1977·Psychosomatic Medicine·S Jacobs, A Ostfeld
Jan 1, 1975·Psychosomatic Medicine·R M RoseT P Gordon
Aug 29, 1991·The New England Journal of Medicine·S CohenA P Smith
Sep 1, 1972·Theoretical Population Biology·I Eshel
Sep 1, 1982·Arteriosclerosis : an Official Journal of the American Heart Association, Inc·J R KaplanD M Taub
Nov 1, 1994·Veterinary Immunology and Immunopathology·M J HessingP R Wiepkema
Dec 20, 1993·Behavioural Brain Research·D C BlanchardR J Blanchard
May 1, 1993·Psychosomatic Medicine·C L Coe
Jul 1, 1993·Psychosomatic Medicine·T B Herbert, S Cohen
Aug 9, 1996·Science·R M Sapolsky
Feb 4, 1998·BMJ : British Medical Journal·G Davey SmithJ Yarnell
May 20, 2000·Annals of the New York Academy of Sciences·G C Román
Mar 29, 2001·Annals of the New York Academy of Sciences·J F SheridanD A Padgett
Apr 27, 2001·The Journal of Biological Chemistry·J C StamP M van Bergen en Henegouwen
Aug 21, 2001·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·I MorH Soreq
Dec 14, 2002·Brain, Behavior, and Immunity·Paul H Black
Mar 5, 2003·Hormones and Behavior·David P McCobbGabriele Flügge
Apr 3, 2004·Proceedings of the National Academy of Sciences of the United States of America·Ella H SklanHermona Soreq
Jul 9, 2004·Annals of the New York Academy of Sciences·Marjorie PickHermona Soreq
Feb 1, 1946·The Journal of Clinical Endocrinology and Metabolism·H SELYE

❮ Previous
Next ❯

Citations

Oct 18, 2007·Proceedings. Biological Sciences·Brendan D O'FallonStephen R Proulx
May 7, 2016·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Joanna Masel, Daniel E L Promislow
Sep 14, 2016·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Yoav Ram, Lilach Hadany
Sep 3, 2013·Social Psychiatry and Psychiatric Epidemiology·Rui GuimarãesMargarida Fonseca Cardoso
Aug 9, 2020·Journal of Experimental Zoology. Part B, Molecular and Developmental Evolution·Jacqueline S R ChinErik R Duboué
Nov 24, 2016·Mathematical Biosciences and Engineering : MBE·Minette HerreraJoel Nishimura

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Proceedings of the National Academy of Sciences of the United States of America
Julio BlasTracy A Marchant
Proceedings of the National Academy of Sciences of the United States of America
S A Cavigelli, M K McClintock
Proceedings of the National Academy of Sciences of the United States of America
Derrick J RossiIrving L Weissman
© 2022 Meta ULC. All rights reserved