Why is there significant overlap in volume status between hypertensive and normotensive patients on dialysis?

American Journal of Nephrology
Li-Tao ChengTao Wang

Abstract

Volume overload is believed to play a pivotal role in the pathogenesis of hypertension in dialysis patients. Although the extracellular water (ECW) content in hypertensive dialysis patients was significantly higher than in normotensive dialysis patients on the whole, there was considerable overlap in ECW between the two groups. Little is known about the hemodynamic characteristics in subgroups of patients with normotension but a high volume (HV) status or with hypertension but a normal volume (NV) status. We investigate the overlap in ECW between controlled and uncontrolled hypertension in dialysis patients. Fifty-two patients (mean age 62 years, 26 males and 26 females) on peritoneal dialysis were enrolled into this study. The ECW was assessed by bioimpedance analysis and normalized by individual height in meters (NECW). The mean value of NECW in both sexes was arbitrarily set to define NV status (lower than mean value) or HV status (higher than mean value). All patients were thus divided into four subgroups: controlled hypertension with NV (CHT-NV), controlled hypertension with HV (CHT-HV), uncontrolled hypertension with NV (UHT-NV) and uncontrolled hypertension with HV (UHT-HV). The stroke volume, cardiac output and total pe...Continue Reading

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Citations

Jul 15, 2015·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Qunying GuoXueqing Yu
Dec 19, 2009·The International Journal of Artificial Organs·Andrew Davenport, Michelle Willicombe
Jun 16, 2012·Blood Purification·Shu-Hong BiSuhail Ahmad
Jan 18, 2017·International Journal of Hypertension·Fei WuChaoshu Tang

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