Why is there still doubt to cut it out?

Epilepsy Currents
Jerome Engel

Abstract

Surgical treatment for epilepsy has made tremendous strides in the past few decades as a result of advances in neurodiagnostics-particularly structural and functional neuroimaging-and improved surgical techniques. This has not only resulted in better outcomes with respect to epileptic seizures and quality of life, and reduced surgical morbidity and mortality, but it has also increased the population of patients now considered as surgical candidates, particularly in the pediatric age range, and enhanced cost-effectiveness sufficient to make surgical treatment available to countries with limited resources. Yet surgical treatment for epilepsy remains arguably the most underutilized of all accepted medical interventions. In the United States, less than 1% of patients with pharmacoresistant epilepsy are referred to epilepsy centers. Although the number of epilepsy surgery centers has increased appreciably over the past two decades, the number of therapeutic surgical procedures performed for epilepsy has not increased at all. For patients who are referred, the average delay from onset of epilepsy to surgery is more than 20 years-too late for many to avoid a lifetime of disability or premature death. Not only has there been no consist...Continue Reading

Associated Clinical Trials

References

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Citations

May 3, 2014·Annals of Indian Academy of Neurology·Jerome Engel
May 29, 2014·Journal of Neurosurgery. Pediatrics·Saadi GhatanSteven M Wolf
Jun 25, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Nealen G LaxpatiRobert E Gross
Mar 1, 2015·Epilepsy & Behavior : E&B·Sandra R Dewar, Huibrie C Pieters
May 29, 2015·Epilepsy & Behavior : E&B·Edward F ChangSumeet Vadera
Jun 9, 2015·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Bin He, Abbas Sohrabpour
May 1, 2015·Neurologia Medico-chirurgica·Takamichi Yamamoto
Feb 2, 2015·Lancet Neurology·Jerome Engel
Jan 21, 2015·Epilepsia·Iván Sánchez FernándezTobias Loddenkemper
Mar 25, 2015·Seizure : the Journal of the British Epilepsy Association·Ramshekhar N Menon, Kurupath Radhakrishnan
Apr 2, 2016·World Neurosurgery·Manas PanigrahiSita Jayalakshmi
May 22, 2016·Neurosurgical Review·Dario J EnglotEdward F Chang
Jul 26, 2016·Frontiers in Neuroanatomy·Elizabeth W Pang, O C Snead Iii
Nov 26, 2016·Journal of Neurosurgery. Pediatrics·Malgosia A KokoszkaSaadi Ghatan
Mar 22, 2018·Brain Sciences·Chinekwu Anyanwu, Gholam K Motamedi
Jan 18, 2017·Archives of Disease in Childhood·Vijay M RavindraRobert J Bollo
Nov 1, 2017·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Aditya VedantamSandi K Lam
Apr 20, 2018·Brain Sciences·Churl-Su KwonNathalie Jetté
Sep 4, 2018·Neurosurgical Focus·Erin N Kiehna, Robert J Bollo
Jul 14, 2017·Journal of Neurology·Iván Sánchez FernándezTobias Loddenkemper
Feb 15, 2021·Seizure : the Journal of the British Epilepsy Association·Pedro Sudbrack-OliveiraAndre Russowsky Brunoni
Feb 19, 2021·Seizure : the Journal of the British Epilepsy Association·Wesley T KerrJohn M Stern
Dec 29, 2018·Seizure : the Journal of the British Epilepsy Association·Christian Hoppe, Christoph Helmstaedter
May 31, 2020·Seizure : the Journal of the British Epilepsy Association·Yusuke OkuboHiroki Nariai
Mar 1, 2019··Johan CazalsQuentin Mermillod

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Methods Mentioned

BETA
surgical resection
pharmacotherapy

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