Why minimally invasive skin sampling techniques? A bright scientific future

Cutaneous and Ocular Toxicology
Christina Y Wang, Howard I Maibach

Abstract

There is increasing interest in minimally invasive skin sampling techniques to assay markers of molecular biology and biochemical processes. This overview examines methodology strengths and limitations, and exciting developments pending in the scientific community. Publications were searched via PubMed, the U.S. Patent and Trademark Office Website, the DermTech Website and the CuDerm Website. The keywords used were noninvasive skin sampling, skin stripping, skin taping, detergent method, ring method, mechanical scrub, reverse iontophoresis, glucose monitoring, buccal smear, hair root sampling, mRNA, DNA, RNA, and amino acid. There is strong interest in finding methods to access internal biochemical, molecular, and genetic processes through noninvasive and minimally invasive external means. Minimally invasive techniques include the widely used skin tape stripping, the abrasion method that includes scraping and detergent, and reverse iontophoresis. The first 2 methods harvest largely the stratum corneum. Hair root sampling (material deeper than the epidermis), buccal smear, shave biopsy, punch biopsy, and suction blistering are also methods used to obtain cellular material for analysis, but involve some degree of increased invasi...Continue Reading

References

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Citations

Jul 23, 2013·Journal of the American Academy of Dermatology·Alvin B CodaRichard L Gallo
Sep 4, 2015·Rapid Communications in Mass Spectrometry : RCM·Gary J Van Berkel, Vilmos Kertesz
Oct 17, 2014·Pharmaceutical Research·Anroop B NairSree Harsha
Dec 24, 2020·Trends in Endocrinology and Metabolism : TEM·Decibel P ElpaPawel L Urban

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