Why minimally invasive skin sampling techniques? A bright scientific future

Cutaneous and Ocular Toxicology
Christina Y Wang, Howard I Maibach


There is increasing interest in minimally invasive skin sampling techniques to assay markers of molecular biology and biochemical processes. This overview examines methodology strengths and limitations, and exciting developments pending in the scientific community. Publications were searched via PubMed, the U.S. Patent and Trademark Office Website, the DermTech Website and the CuDerm Website. The keywords used were noninvasive skin sampling, skin stripping, skin taping, detergent method, ring method, mechanical scrub, reverse iontophoresis, glucose monitoring, buccal smear, hair root sampling, mRNA, DNA, RNA, and amino acid. There is strong interest in finding methods to access internal biochemical, molecular, and genetic processes through noninvasive and minimally invasive external means. Minimally invasive techniques include the widely used skin tape stripping, the abrasion method that includes scraping and detergent, and reverse iontophoresis. The first 2 methods harvest largely the stratum corneum. Hair root sampling (material deeper than the epidermis), buccal smear, shave biopsy, punch biopsy, and suction blistering are also methods used to obtain cellular material for analysis, but involve some degree of increased invasi...Continue Reading


Nov 1, 1978·The British Journal of Dermatology·M E McBrideJ M Knox
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Jul 16, 2004·Physiological Measurement·Benoît LeboulangerM Begoña Delgado-Charro
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Apr 6, 2005·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·F DreherH I Maibach
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May 1, 2008·Journal of Pharmacy & Pharmaceutical Sciences : a Publication of the Canadian Society for Pharmaceutical Sciences, Société Canadienne Des Sciences Pharmaceutiques·J J Escobar-ChávezA Ganem-Quintanar
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Aug 8, 2008·Current Opinion in Clinical Nutrition and Metabolic Care·Andrea Tura
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Jul 10, 2009·Biological Trace Element Research·Hassan Imran AfridiMohammad Balal Arain
Jul 25, 2009·Journal of Applied Toxicology : JAT·Abraar KaranHoward I Maibach
Sep 15, 2009·The Journal of Allergy and Clinical Immunology·Carolyn J BroccardoDonald Y M Leung
Oct 7, 2009·Pharmaceutical Research·Camille C BouissouM Begoña Delgado-Charro
Dec 18, 2009·Skin Pharmacology and Physiology·J M JungerstedT Agner
Jan 21, 2010·Annals of Biomedical Engineering·Congo Tak-Shing ChingChung-Yuan Chen
Feb 16, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Julie Dutet, M Begoña Delgado-Charro
May 12, 2010·Skin Research and Technology : Official Journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI)·Shu SakuyamaSatoshi Yoshida

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Jul 23, 2013·Journal of the American Academy of Dermatology·Alvin B CodaRichard L Gallo
Sep 4, 2015·Rapid Communications in Mass Spectrometry : RCM·Gary J Van Berkel, Vilmos Kertesz
Oct 17, 2014·Pharmaceutical Research·Anroop B NairSree Harsha
Dec 24, 2020·Trends in Endocrinology and Metabolism : TEM·Decibel P ElpaPawel L Urban

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