Why monkeys do not get multiple sclerosis (spontaneously): An evolutionary approach

Evolution, Medicine, and Public Health
Riley Bove

Abstract

The goal of this review is to apply an evolutionary lens to understanding the origins of multiple sclerosis (MS), integrating three broad observations. First, only humans are known to develop MS spontaneously. Second, humans have evolved large brains, with characteristically large amounts of metabolically costly myelin. This myelin is generated over long periods of neurologic development-and peak MS onset coincides with the end of myelination. Third, over the past century there has been a disproportionate increase in the rate of MS in young women of childbearing age, paralleling increasing westernization and urbanization, indicating sexually specific susceptibility in response to changing exposures. From these three observations about MS, a life history approach leads us to hypothesize that MS arises in humans from disruption of the normal homeostatic mechanisms of myelin production and maintenance, during our uniquely long myelination period. This review will highlight under-explored areas of homeostasis in brain development, that are likely to shed new light on the origins of MS and to raise further questions about the interactions between our ancestral genes and modern environments.

References

Nov 18, 1989·BMJ : British Medical Journal·D P Strachan
Dec 25, 1986·The New England Journal of Medicine·G C EbersT Grey
Aug 17, 1973·Nature·R F GledhillW I McDonald
Sep 3, 1996·Proceedings of the National Academy of Sciences of the United States of America·D LütjohannI Björkhem
Apr 1, 1997·Tropical Medicine & International Health : TM & IH·J G TshikukaK N Olela
Mar 14, 1998·Proceedings of the National Academy of Sciences of the United States of America·K HawkesE L Charnov
Jul 31, 1998·The New England Journal of Medicine·C ConfavreuxT Moreau
Apr 1, 1999·Journal of Women's Health·B I Strassmann
Sep 24, 1999·Nature Neuroscience·J N GieddJ L Rapoport
Nov 21, 2000·Molecular and Cellular Neurosciences·G L Hinks, R J Franklin
Feb 13, 2001·Trends in Neurosciences·J M LevineJ W Fawcett
Mar 29, 2001·Physiological Reviews·N Baumann, D Pham-Dinh
May 4, 2001·Journal of Reproductive Immunology·S S SouzaJ C Voltarelli
Dec 26, 2001·Neuropsychologia·Pauline M MakiR Shayna Rosenbaum
Feb 19, 2002·Nature Neuroscience·K SemendeferiH Damasio
Sep 20, 2002·The New England Journal of Medicine·Jean-Francois Bach
Jan 2, 2003·Pediatrics·William Cameron ChumleaShumei S Sun
Jan 23, 2004·Brain : a Journal of Neurology·S J HickmanD H Miller
Dec 22, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Erica J Crespi, Robert J Denver
Dec 22, 2004·American Journal of Human Biology : the Official Journal of the Human Biology Council·Peter T Ellison
Mar 25, 2005·Proceedings of the National Academy of Sciences of the United States of America·Giuseppe MatareseSerafino Zappacosta
Aug 24, 2005·Nature Neuroscience·Sara L BengtssonFredrik Ullén
Oct 22, 2005·Annals of Neurology·Giovanni RistoriMarco Salvetti
Apr 25, 2006·American Journal of Human Biology : the Official Journal of the Human Biology Council·Robert WalkerTaro Yamauchi
Jun 13, 2006·Multiple Sclerosis : Clinical and Laboratory Research·J S SlokaM Stefanelli
Aug 16, 2006·Proceedings of the National Academy of Sciences of the United States of America·Grazyna JasienskaPeter T Ellison
Oct 11, 2007·Obstetrical & Gynecological Survey·Anna Blackburn Wittman, L Lewis Wall
Dec 8, 2007·Clinical and Experimental Immunology·L AirasUNKNOWN Finnish Multiple Sclerosis and Pregnancy Study Group
Jan 30, 2008·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·Klaus SchmiererDavid H Miller
Feb 15, 2008·Pediatrics·Paul B Kaplowitz
May 6, 2008·Hormones and Behavior·Kristen L MordecaiPauline M Maki

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Citations

Sep 29, 2020·Frontiers in Neuroscience·Pieter VancampSylvie Remaud
Dec 7, 2019·Brain Research·Mohammed A Mostajo-RadjiAlex A Pollen
Jan 8, 2021·Theoretical Biology & Medical Modelling·Gianluigi Zangari Del Balzo
Apr 19, 2020·Early Human Development·Sibel GaziogluCavit Boz
May 13, 2021·Multiple Sclerosis and Related Disorders·Philipp GuldePeter Rieckmann
May 9, 2021·Medical Hypotheses·Sarai M KeestraGul Deniz Salali
Aug 26, 2021·Scientific Reports·Philipp GuldePeter Rieckmann

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