Why Oats Are Safe and Healthy for Celiac Disease Patients

Medical Sciences : Open Access Journal
Luud J W J GilissenMarinus J M Smulders

Abstract

The water-insoluble storage proteins of cereals (prolamins) are called "gluten" in wheat, barley, and rye, and "avenins" in oat. Gluten can provoke celiac disease (CD) in genetically susceptible individuals (those with human leukocyte antigen (HLA)-DQ2 or HLA-DQ8 serotypes). Avenins are present at a lower concentration (10%-15% of total protein content) in oat as compared to gluten in wheat (80%-85%). The avenins in the genus Avena (cultivated oat as well as various wild species of which gene bank accessions were analyzed) are free of the known CD immunogenic epitopes from wheat, barley, and rye. T cells that recognize avenin-specific epitopes have been found very rarely in CD patients. CD patients that consume oats daily do not show significantly increased levels of intraepithelial lymphocyte (EIL) cells. The safety and the positive health effects of the long-term inclusion of oats in the gluten-free diet have been confirmed in long-term studies. Since 2009 (EC 41/2009) and 2013 (FDA) oat products may be sold as gluten-free in several countries provided a gluten contamination level below 20 ppm. Introduction of oats in the gluten-free diet of celiac patients is advised after the recovery of the intestine. Health effects of oat...Continue Reading

References

Oct 19, 1995·The New England Journal of Medicine·E K JanatuinenR J Julkunen
Mar 5, 2003·Journal of the American Dietetic Association·Tricia Thompson
Oct 23, 2003·Gut·K E A LundinK Kett
Jun 10, 2004·Atherosclerosis·Liping LiuMohsen Meydani
Nov 5, 2004·The New England Journal of Medicine·Tricia Thompson
Nov 5, 2004·PLoS Medicine·Helene Arentz-HansenLudvig M Sollid
Jul 29, 2005·Immunological Reviews·Bana JabriPeter H R Green
May 8, 2008·Archives of Dermatological Research·Runa SurMichael D Southall
May 10, 2008·European Journal of Gastroenterology & Hepatology·Alberto HernandoEnrique Méndez
Jul 15, 2009·Advances in Food and Nutrition Research·Olga M PulidoSamuel Benrejeb Godefroy
May 26, 2010·Journal of the American Dietetic Association·Tricia ThompsonThomas Grace
May 31, 2011·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·T B KoernerH Elamparo
Nov 10, 2013·Nutrients·Katri KaukinenMarkku Mäki
Nov 19, 2013·European Journal of Nutrition·Marco SilanoPatrizia Restani
Apr 30, 2014·Nature Structural & Molecular Biology·Jan PetersenJamie Rossjohn
Oct 1, 2014·The British Journal of Nutrition·Derek Stewart, Gordon McDougall
Mar 22, 2015·Journal of Chromatography. a·Hetty C van den BroeckIngrid M van der Meer
Sep 10, 2015·Proceedings of the National Academy of Sciences of the United States of America·Marta Mariotti LippiAnna Revedin
Feb 9, 2016·Food & Nutrition Research·Isabel CominoCarolina Sousa
Jul 23, 2016·Canadian Journal of Gastroenterology & Hepatology·Sébastien La VieilleSamuel Godefroy
Sep 7, 2016·Food Chemistry·Ronald D FritzVeronica Contreras

❮ Previous
Next ❯

Citations

Oct 17, 2019·Frontiers in Pediatrics·Inna Spector CohenRon Shaoul
Oct 5, 2019·Nutrients·Iva HoffmanováHelena Tlaskalová-Hogenová
Sep 1, 2019·Comprehensive Reviews in Food Science and Food Safety·Fred BrounsDaisy Jonkers
Dec 22, 2020·Frontiers in Nutrition·Karla A BascuñánLeda Roncoroni
Oct 19, 2021·Frontiers in Nutrition·Gyöngyvér GellFerenc Békés
Dec 14, 2021·Frontiers in Plant Science·Francisco J CanalesElena Prats

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Journal of the American Dietetic Association
T Thompson
Nutrition Reviews
Premysl FricJiri Nevoral
European Journal of Gastroenterology & Hepatology
William Dickey
Current Allergy and Asthma Reports
Jolanda M Denham, Ivor D Hill
© 2022 Meta ULC. All rights reserved