Why patients don't take part in cancer clinical trials: an overview of the literature

European Journal of Cancer Care
K Cox, J McGarry

Abstract

Clinical trials have been recognized extensively within the literature as a crucial component in the research, development and evaluation of treatment strategies within health care services. However, it has also been acknowledged that clinicians and researchers have historically experienced problems in terms of attaining adequate recruitment to clinical trials. The purpose of this review is to explore some of these questions and, more importantly, provide possible explanations for non-participation in clinical trials, with specific reference to the field of cancer research. In addition, approaches that have been used by researchers in order to explore the issue of non-participation, and suggestions in terms of the ways that further research into this key area may be undertaken, are also be considered.

References

Jan 4, 1992·BMJ : British Medical Journal·R D RubensA R Timothy
Oct 26, 1991·BMJ : British Medical Journal·G M Mead, C J Williams
Nov 1, 1991·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A B BensonK Anderson
Apr 28, 1990·Lancet·I S FentimanM S Aapro
Nov 1, 1986·CA: a Cancer Journal for Clinicians·M Markman
Apr 1, 1984·European Journal of Cancer & Clinical Oncology·S RodenhuisN H Mulder
Jul 1, 1984·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D T PenmanR Cherry
Aug 27, 1982·JAMA : the Journal of the American Medical Association·M B Lipsett
Aug 27, 1982·JAMA : the Journal of the American Medical Association·B R CassilethS Hurwitz
May 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C DaughertyM Siegler
Aug 1, 1994·British Journal of Cancer·C A Stiller
Apr 1, 1996·Journal of Community Health·S B RobinsonM A Haynes
Dec 1, 1996·Controlled Clinical Trials·K S HudmonR J Winn
Nov 14, 1997·Annals of Epidemiology·R B NessJ A Grisso
Jan 24, 1998·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J CockburnA Kricker
Dec 16, 1998·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C J TwelvesA Gould
Dec 22, 1998·Acta Oncologica·E Saksela
Feb 16, 1999·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·M A RichardsonB Justice
Aug 12, 1999·The Australian and New Zealand Journal of Surgery·P M EllisS M Dunn
Sep 2, 1999·Annals of Oncology : Official Journal of the European Society for Medical Oncology·V CottinV Trillet-Lenoir
Oct 3, 1999·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·T L AlbrechtR Strongbow
Jan 7, 2000·Southern Medical Journal·C N KlabundeJ Atkins
Mar 30, 2000·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·J LingJ Hardy
Jan 13, 2001·Journal of Internal Medicine·S M MadsenP Riis
Feb 24, 2001·Social Science & Medicine·V S FreimuthT Duncan
Feb 27, 2001·Journal of Clinical Epidemiology·D A BraunholtzR J Lilford
Mar 10, 2001·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·C A Sawka, K I Pritchard
May 12, 2001·The Breast Journal·Deborah E. Collyar

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Citations

Oct 26, 2005·Archives of Internal Medicine·Peter J EmbiC Martin Harris
Sep 24, 2010·Journal of Cancer Education : the Official Journal of the American Association for Cancer Education·Karen A StepanScott B Cantor
Mar 4, 2005·Surgical Infections·Philip S Barie
May 25, 2010·Japanese Journal of Clinical Oncology·Keiko SatoTakuji Okusaka
Feb 23, 2013·The Oncologist·Diane A J van der BiessenRon H J Mathijssen
Dec 3, 2008·The Journal of Bone and Joint Surgery. American Volume·Lori A DolanKevin F Spratt
Jan 25, 2014·BMC Medical Research Methodology·Lisa Newington, Alison Metcalfe
Dec 20, 2007·Nursing for Women's Health·Rebecca J HelmreichErica Chow
Jan 17, 2016·International Journal of Orthopaedic and Trauma Nursing·Jeremy HorwoodRachael Gooberman-Hill
Apr 4, 2013·Taiwanese Journal of Obstetrics & Gynecology·Yukiharu Todo, Noriaki Sakuragi
Sep 22, 2007·Journal of Clinical Epidemiology·Debra FayterAlison Eastwood
Apr 29, 2006·European Journal of Cancer Care·S Maslin-Prothero
Feb 22, 2011·Health Expectations : an International Journal of Public Participation in Health Care and Health Policy·Ikumi OkamotoClaire Foster
May 12, 2015·Journal of Racial and Ethnic Health Disparities·Jennifer A WenzelJean G Ford
Apr 25, 2012·Patient Education and Counseling·Kristen J WellsPaul B Jacobsen
Feb 11, 2015·Patient Education and Counseling·James Price DillardAndrea Manni
Jan 17, 2015·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Jennifer A H Bell, Lynda G Balneaves
Aug 28, 2010·Oncology Nursing Forum·Karen A StepanScott B Cantor
Apr 5, 2011·International Journal of Medical Informatics·Marc CuggiaDavid Glasspool
Jan 31, 2013·Psychology, Health & Medicine·Shayesta Dhalla, Gary Poole
Jun 19, 2014·Journal of Feline Medicine and Surgery·Margaret E GruenB Duncan X Lascelles
Jan 19, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·C Daniel MullinsUNKNOWN American Society of Clinical Oncology
May 23, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul B JacobsenDaniel Sullivan
Apr 30, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Carol A TownsleyLillian L Siu
Apr 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Nancy E AvisEdgardo Rivera
Jul 1, 2015·Journal of Empirical Research on Human Research Ethics : JERHRE·Jennifer H LinglerLauren A Terhorst
Mar 29, 2018·Trials·Sumedha ChhatreRavishankar Jayadevappa
Nov 28, 2015·The Cochrane Database of Systematic Reviews·Katie GilliesZoe Skea
Apr 7, 2007·Clinical Neuropharmacology·UNKNOWN Parkinson Study Group

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