Mar 12, 2013

Why should autophagic flux be assessed?

Acta Pharmacologica Sinica
Xiao-jie ZhangWeidong Le

Abstract

As autophagy is involved in cell growth, survival, development and death, impaired autophagic flux has been linked to a variety of human pathophysiological processes, including neurodegeneration, cancer, myopathy, cardiovascular and immune-mediated disorders. There is a growing need to identify and quantify the status of autophagic flux in different pathological conditions. Given that autophagy is a highly dynamic and complex process that is regulated at multiple steps, it is often assessed accurately. This perspective review article will focus on the autophagic flux defects in different human disorders and update the current methods of monitoring autophagic flux. This knowledge is essential for developing autophagy-related therapeutics for treating the diseases.

  • References47
  • Citations62

Mentioned in this Paper

Immune System Diseases
Degenerative Diseases, Spinal Cord
Nerve Degeneration
Myopathy
Cardiovascular Diseases
Cell Growth
Programmed Cell Death, Type II
Pathology
Malignant Neoplasms
Infantile Neuroaxonal Dystrophy

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