Why was the 2009 influenza pandemic in England so small?

PloS One
Ruben J Kubiak, Angela R McLean

Abstract

The "Swine flu" pandemic of 2009 caused world-wide infections and deaths. Early efforts to understand its rate of spread were used to predict the probable future number of cases, but by the end of 2009 it was clear that these predictions had substantially overestimated the pandemic's eventual impact. In England, the Health Protection Agency made announcements of the number of cases of disease, which turned out to be surprisingly low for an influenza pandemic. The agency also carried out a serological survey half-way through the English epidemic. In this study, we use a mathematical model to reconcile early estimates of the rate of spread of infection, weekly data on the number of cases in the 2009 epidemic in England and the serological status of the English population at the end of the first pandemic wave. Our results reveal that if there are around 19 infections (i.e., seroconverters) for every reported case then the three data-sets are entirely consistent with each other. We go on to discuss when in the epidemic such a high ratio of seroconverters to cases of disease might have been detected, either through patterns in the case reports or through even earlier serological surveys.

References

Aug 15, 2002·British Medical Bulletin·Almut Scherer, Angela McLean
May 9, 2009·The New England Journal of Medicine·Fatimah S DawoodTimothy M Uyeki
May 13, 2009·Science·Christophe FraserUNKNOWN WHO Rapid Pandemic Assessment Collaboration
Aug 8, 2009·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·U C de SilvaM Chittaganpitch
Aug 26, 2009·Influenza and Other Respiratory Viruses·Babak PourbohloulRobert C Brunham
Oct 20, 2009·Population Trends·Steve Smallwood, Sofie De Broe
Nov 4, 2009·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Es McBrydeJe Fielding
Nov 7, 2009·Emerging Infectious Diseases·Honglin ChenYi Guan
Dec 5, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Ashleigh R TuiteDavid N Fisman
Dec 17, 2009·BMJ : British Medical Journal·Liam J DonaldsonIain E Yardley
Jan 1, 2010·The New England Journal of Medicine·Simon CauchemezNeil M Ferguson
Jan 1, 2010·The New England Journal of Medicine·Justin LesslerN Thompson
Jan 9, 2010·Theoretical Biology & Medical Modelling·Hiroshi NishiuraCarlos Castillo-Chavez
Jun 18, 2010·Vaccine·Marc P GirardMarie Paule Kieny
Jan 26, 2011·Journal of Health, Population, and Nutrition·Slinporn PrachayangprechaYong Poovorawan
Jun 4, 2011·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·J DelangueX de Lamballerie
Nov 15, 2011·Influenza and Other Respiratory Viruses·Malinee ChittaganpitchPathom Sawanpanyalert

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