Wide-range CRP versus high-sensitivity CRP on Roche analyzers: focus on low-grade inflammation ranges and high-sensitivity cardiac troponin T levels

Scandinavian Journal of Clinical and Laboratory Investigation
Denis MonneretDominique Bonnefont-Rousselot

Abstract

Wide-range C-reactive protein (wr-CRP) has been proposed as an economical alternative to high-sensitivity C-reactive protein (hs-CRP) for the evaluation of low-grade inflammation-associated cardiovascular risk (LGI-CVR). Concomitant values of serum hs-CRP and plasma wr-CRP ≤5 mg/L, and high-sensitivity cardiac troponin T (hs-cTnT), all assayed on Roche Diagnostics analyzers over a 1.8-year period, were extracted from a hospital laboratory database. Hs-CRP and wr-CRP values were compared (Bland-Altman method; Deming's correlation), then separately classified into low (<1 mg/L), moderate (1-3 mg/L) and high (>3 mg/L) LGI-CVR ranges for agreement test (κ), assessed before and after Deming's regression-based adjustment of wr-CRP (Adj-wr-CRP). Wr-CRP and hs-CRP values were strongly correlated, with linearity, whether below 5 mg/L (n = 744; τ = 0.933; p < .001) or below 1 mg/L (n = 283; τ = 0.823; p < .001). Overall, wr-CRP values were lower than hs-CRP (mean bias: -0.11 ± 0.17 mg/L). Agreement was good, with 8.1% of wr-CRP values misclassified compared to hs-CRP (κ: 0.874), and weakly improved after regression-based adjustment (7.7% reclassified values; κ: 0.881). Lowering the Adj-wr-CRP cutoff of the moderate LGI-CVR subrange from ...Continue Reading

References

Apr 3, 1997·The New England Journal of Medicine·P M RidkerC H Hennekens
Jan 14, 1999·The New England Journal of Medicine·R Ross
Jun 30, 2001·The New England Journal of Medicine·P M RidkerUNKNOWN Air Force/Texas Coronary Atherosclerosis Prevention Study Investigators
Jul 16, 2005·Clinica Chimica Acta; International Journal of Clinical Chemistry·Ori RogowskiShlomo Berliner
Jun 16, 2006·Acta Neurologica Scandinavica·S Shenhar-TsarfatyN M Bornstein
Jul 12, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Diana C GrootendorstUNKNOWN NECOSAD Study Group
Dec 4, 2008·Clinical Nephrology·N KanaanM Jadoul
Jun 18, 2009·Scandinavian Journal of Clinical and Laboratory Investigation·Jeppe ZachoBørge Grønne Nordestgaard
Nov 17, 2010·JAMA : the Journal of the American Medical Association·Christopher R deFilippiStephen L Seliger
Nov 27, 2010·Scandinavian Journal of Clinical and Laboratory Investigation·Marina J HarutyunyanUNKNOWN CLARICOR Trial Group
Dec 9, 2010·JAMA : the Journal of the American Medical Association·James A de LemosDarren K McGuire
Mar 27, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Annika TaubeJuergen Eckel
Dec 12, 2012·Annals of Epidemiology·Oludamilola W OluleyeUNKNOWN ARIC Study Investigators
Aug 27, 2013·Journal of the American College of Cardiology·Ayman A HusseinDonald Lloyd-Jones
Aug 26, 2014·Clinical Chemistry and Laboratory Medicine : CCLM·Nils KusterJean-Paul Cristol
Feb 25, 2015·JAMA : the Journal of the American Medical Association·Andrew S LeveyLesley A Inker
May 16, 2015·Clinical Biochemistry·Jason Zhi Yong Chung, Graham Ross Dallas Jones
Feb 13, 2016·Journal of the American College of Cardiology·Paul M Ridker
Jun 14, 2017·Clinica Chimica Acta; International Journal of Clinical Chemistry·Tomer Ziv-BaranOri Rogowski

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