Wide variability in Pseudomonas aeruginosa aminoglycoside results among seven susceptibility testing procedures.

Journal of Clinical Microbiology
J L StaneckP A Leist

Abstract

Seven commonly used antimicrobial susceptibility testing methods were used to test the susceptibility of 150 isolates of Pseudomonas aeruginosa against gentamicin, tobramycin, amikacin, carbenicillin, and piperacillin. Results were compared with respect to the susceptibility characteristics of the population of isolates as defined by each method. Conventional methods included agar disk diffusion and agar dilution, carried out in accordance with current recommendations of the National Committee for Clinical Laboratory Standards, as well as broth microdilution testing with cation-supplemented Mueller-Hinton broth (CSMHB). Methods in which instrumentation was used for result determination included the Autobac I, Avantage, Sensititre Autoreader (using a breakpoint panel at 18 h of incubation), and Vitek (AMS-240, using the GNS susceptibility card). When necessary for comparison, MIC data were converted to categorical interpretations (susceptible, intermediate, and resistant). With respect to gentamicin, no significant differences were noted among the results of disk diffusion, broth microdilution, Sensititre Auto breakpoint, or Vitek methods which characterized 60 to 67% of isolates as susceptible, 16 to 22% as intermediate, and 13...Continue Reading

References

Mar 11, 1975·American Journal of Clinical Pathology·C C Sanders, W E Sanders
Nov 1, 1973·Applied Microbiology·R C TiltonE H Gerlach
Jun 1, 1972·Antimicrobial Agents and Chemotherapy·S D Davis, A Iannetta
Sep 1, 1969·Journal of Clinical Pathology·L P Garrod, P M Waterworth
Jan 1, 1980·Antimicrobial Agents and Chemotherapy·M A KennyF D Schoenknecht

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