Wide variation in microsatellite sequences within each Pfcrt mutant haplotype

Molecular and Biochemical Parasitology
Sumiti VinayakYagya D Sharma

Abstract

Flanking microsatellites for each of the Pfcrt mutant haplotype of Plasmodium falciparum remain conserved among geographical isolates. We describe here heterogeneity in the intragenic microsatellites among each of the Pfcrt haplotype. There were fourteen different alleles of AT repeats of intron 2 and eight alleles of TA repeats of intron 4 of the pfcrt gene among Indian isolates. This resulted in 33 different two-locus (intron 2 plus intron 4) microsatellite genotypes among 224 isolates. There were 15 different two-locus microsatellite genotypes within the South American Pfcrt haplotype (S72V73M74N75T76S220) and 11 genotypes in the southeast Asian haplotype (C72V73I74E75T76S220) in these isolates. Indian isolates with Pfcrt haplotype C72V73I74E75T76S220 shared one of its two-locus microsatellite genotype with southeast Asian P. falciparum parasite lines from Thailand (K1) and Indochina (Dd2 and W2). Conversely, Indian isolates containing S72V73M74N75T76S220 Pfcrt haplotype did not share any of their two-locus microsatellite genotype with South American parasite line 7G8 from Brazil. Significantly, large number of newer two-locus microsatellite genotypes were detected in a 2-year time period (P<0.05). Microsatellite variation w...Continue Reading

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Citations

Aug 24, 2010·Journal of Molecular Evolution·John C TanMichael T Ferdig
Dec 31, 2011·The Journal of Antimicrobial Chemotherapy·Vanshika LumbYagya D Sharma
Jun 23, 2010·Malaria Journal·Bianca E GamaMaria de Fátima Ferreira-da-Cruz
Jan 10, 2014·Memórias do Instituto Oswaldo Cruz·Gauri Awasthi, Aparup Das
Oct 30, 2009·Trends in Parasitology·Ananias A EscalanteYuseob Kim
Sep 8, 2009·Trends in Parasitology·Vineeta SinghAparup Das
Oct 26, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kshipra ChauhanAparup Das
Jun 10, 2014·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Kshipra ChauhanAparup Das
Feb 7, 2007·Trends in Parasitology·Aparup Das, Aditya Prasad Dash
Oct 16, 2013·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Prashant K MallickNeena Valecha
Jul 28, 2016·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Moytrey ChatterjeeArdhendu Kumar Maji
Apr 10, 2007·Molecular and Biochemical Parasitology·Mohammad Tauqeer AlamYagya D Sharma
Feb 23, 2011·Memórias do Instituto Oswaldo Cruz·Sasmita Kumari Das SutarAparup Das
Feb 9, 2012·Memórias do Instituto Oswaldo Cruz·Gauri AwasthiAparup Das

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