PMID: 7428798Aug 1, 1980Paper

Wide variation in serum chlorpropamide concentration in outpatients

European Journal of Clinical Pharmacology
U Bergman Ostman

Abstract

Serum chlorpropamide concentrations (s-CPA) were determined and related to clinical findings in 83 outpatients with maturity onset diabetes. The daily doses of CPA (mg/kg) varied six-fold, but s-CPA ranged 18-fold between the patients. There was a significant correlation between dose and s-CPA (r = 0.61), which rose to 0.75 in the 30 patients who had prescribed no other drugs. Patients given other drugs concomitantly were over-represented amongst subjects with extreme values of apparent plasma clearance of CPA. There was no correlation either between serum creatinine or age and s-CPA. Of the 83 patients 40 (48%) had acceptable blood and urinary glucose values according to our criteria; but as 17 were overweight, only 23 patients (28%) had acceptable clinical control. Of the remaining 60 patients, too low a dose was being given to only 12, and dietary failure was the most probable explanation in the others. Thirteen patients (16%) probably did not need CPA. It is likely that this is a partial explanation for the high utilisation of oral antidiabetic drugs in Sweden. There was no general correlation between dose or s-CPA and blood glucose values, but analysis of s-CPA may still be of value in explaining unexpected changes in clin...Continue Reading

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Citations

Aug 1, 1980·European Journal of Clinical Pharmacology· Wilholm B-E
Jan 1, 1982·European Journal of Clinical Pharmacology·E Wåhlin-BollB Scherstén
Jan 1, 1990·European Journal of Clinical Pharmacology·J KallioK Pyykkö
Sep 15, 1995·European Journal of Pharmacology·Y InoueT Kaneko
Nov 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·G S Meneilly, D Tessier
Dec 23, 2003·Journal of Internal Medicine·U-B LöfgrenF H Nystrom
Jun 1, 1985·Scandinavian Journal of Clinical and Laboratory Investigation·J Thode

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