Wide versus narrow excision margins for high-risk, primary cutaneous melanomas: long-term follow-up of survival in a randomised trial

The Lancet Oncology
Andrew J HayesReconstructive and Aesthetic Surgeons, and the Scottish Cancer Therapy Network

Abstract

The necessary margin of excision for cutaneous melanomas greater than 2 mm in thickness is controversial. At a median follow-up of 5 years, findings from our previously published randomised trial of narrow (1 cm) versus wide (3 cm) excision margins in patients with thick cutaneous melanomas showed that narrow margins were associated with an increased frequency of locoregional relapse, but no significant difference in overall survival was apparent. We now report a long-term survival analysis of that trial. We did a randomised, open-label multicentre trial in 59 hospitals--57 in the UK, one in Poland, and one in South Africa. Patients with one primary localised cutaneous melanoma greater than 2 mm in Breslow thickness on the trunk or limbs (excluding palms or soles) were randomly assigned (1:1) centrally to receive surgery with either a 1 cm or 3 cm excision margin following an initial surgery. The randomisation lists were generated with random permuted blocks and stratified by centre and extent of initial surgery. The endpoints of this analysis were overall survival and melanoma-specific survival. Analyses were done in the intention-to-treat population. This trial was not registered because it predated mandatory trial registrati...Continue Reading

Associated Clinical Trials

References

Sep 22, 1977·The New England Journal of Medicine·U VeronesiN N Trapeznikov
Mar 22, 2001·Annals of Surgical Oncology·C M BalchUNKNOWN Investigators from the Intergroup Melanoma Surgical Trial
Apr 4, 2003·Cancer·David KhayatUNKNOWN French Group of Research on Malignant Melanoma
Feb 20, 2004·The New England Journal of Medicine·J Meirion ThomasUNKNOWN Scottish Cancer Therapy Network
May 28, 2004·The New England Journal of Medicine·Samuel Hellman
Nov 18, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Charles M BalchVernon K Sondak
Apr 10, 2010·Annals of Surgical Oncology·Seng-jaw SoongUNKNOWN AJCC Melanoma Task Force
Apr 27, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·John F ThompsonVernon K Sondak
Sep 27, 2012·Annals of Surgical Oncology·Laura E HudsonKeith A Delman

❮ Previous
Next ❯

Citations

Jan 23, 2016·The Lancet Oncology·Marc Moncrieff
Nov 13, 2015·Annals of Surgical Oncology·Merrick I Ross, Charles M Balch
Dec 17, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·A BerrocalS M Algarra
Jun 2, 2016·The British Journal of Surgery·R Olofsson Bagge, L Ny
Jul 2, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeUNKNOWN European Organisation for Research and Treatment of Cancer (EORTC)
Jul 17, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·S PasqualiC R Rossi
Jul 28, 2016·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·M C T van ZeijlM W J M Wouters
Sep 27, 2016·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Charlotte M C Oude OphuisCornelis Kees Verhoef
Sep 1, 2016·Journal of the European Academy of Dermatology and Venereology : JEADV·F Costa SvedmanJ Hansson
Jan 26, 2017·Chemical Communications : Chem Comm·Yi WangMarcel P Bruchez
Jun 2, 2016·American Society of Clinical Oncology Educational Book·Alexander C J van AkkooiPaul Lorigan
Nov 28, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·Georg LoddeSelma Ugurel
May 13, 2020·Giornale Italiano Di Dermatologia E Venereologia : Organo Ufficiale, Società Italiana Di Dermatologia E Sifilografia·Giuseppe ArgenzianoPiergiacomo Calzavara Pinton
Sep 21, 2018·Molecular and Clinical Oncology·Yuki MaruyamaYasutomo Nasu
Dec 14, 2017·Clinical and Experimental Dermatology·A DesaiA Khachemoune
Jun 28, 2018·Annals of Surgical Oncology·Daniel Coit, Charlotte Ariyan
May 1, 2017·Melanoma Management·Brian D WernickJeffrey M Farma
Apr 28, 2019·Current Oncology Reports·Alberto Falk DelgadoAnna Falk Delgado
Feb 16, 2017·Molecular & Cellular Oncology·Zachary HothemGeorge D Wilson
Jun 1, 2018·Annals of Surgical Oncology·Marc D MoncrieffMichael A Henderson
Apr 3, 2019·Nature Biomedical Engineering·David C YeoChenjie Xu
Aug 30, 2019·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·Werner Hohenberger
Aug 28, 2020·Frontiers in Bioengineering and Biotechnology·Serkan YamanKytai T Nguyen
Oct 28, 2019·Annals of Surgical Oncology·C V AngelesG Karakousis
Sep 29, 2019·Annals of Surgical Oncology·C V AngelesG Karakousis
Nov 30, 2019·The Journal of Dermatology·Yasuhiro NakamuraMakoto Sugaya
Mar 25, 2020·Der Pathologe·Georg LoddeSelma Ugurel
Dec 28, 2016·Current Opinion in Oncology·Reinhard DummerRalph P Braun
Dec 24, 2019·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Claus GarbeUNKNOWN European Dermatology Forum (EDF), the European Association of Dermato-Oncology (EADO), and the European Organization for Res
Jan 20, 2021·Head & Neck·Ryan P GoepfertJeffrey E Gershenwald
Mar 3, 2021·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·M MajemA Berrocal
Mar 13, 2021·Surgical Oncology Clinics of North America·Jennifer H AldrinkMary Austin
Mar 17, 2021·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Sarah HannaRobyn Pm Saw
Apr 25, 2019·Journal of the American Academy of Dermatology·Joy H KunishigeJohn A Zitelli
Mar 25, 2021·Hematology/oncology Clinics of North America·Lilit Karapetyan, John M Kirkwood
May 29, 2021·Advances in Therapy·Erica B FriedmanJohn F Thompson
Jul 25, 2021·International Journal of Molecular Sciences·Verdiana TrappettiValentin G Djonov
Jul 21, 2021·Hematology/oncology Clinics of North America·Gino K InAnn W Silk
Sep 4, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Rina DuHaining Gao
Oct 6, 2021·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·E Dimitra BednarMohannad Abu-Hilal

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection
biopsy

Clinical Trials Mentioned

NCT02385214

Software Mentioned

Stata
R

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.