Widely Spread Unilateral Inflammatory Linear Verrucous Epidermal Nevus (ILVEN)

Case Reports in Dermatology
Kayo TanitaSetsuya Aiba

Abstract

Inflammatory linear verrucous epidermal nevus (ILVEN) is an epidermal nevus that clinically and histologically mimics linear psoriasis. The pathogenesis of psoriasis has been widely investigated, with recent studies focusing especially on targeting proinflammatory cytokines such as IL-17A, TNFα, IL-23, and IL-12, while little is known about ILVEN. Since the treatment for ILVEN varies widely from the administration of topical ointment for psoriasis to invasive methods such as carbon dioxide gas laser, the differential diagnosis between ILVEN and psoriasis is necessary. In this report, we describe a case of widely spread unilateral ILVEN that clinically and histologically mimicked psoriasis vulgaris and could be diagnosed by immunohistochemical staining focused on the IL-36γ/IL-17A axis.

References

Mar 21, 2002·The Australasian Journal of Dermatology·S H Lee, M Rogers
Feb 18, 2006·Dermatology : International Journal for Clinical and Investigative Dermatology·Rudolf Happle
Jun 26, 2008·Pediatric Dermatology·Naheed AbbasiJulie V Schaffer
Sep 2, 2011·The Journal of Investigative Dermatology·Yijun CarrierQuintus G Medley
May 18, 2012·Dermatologic Therapy·Antonietta D'AntuonoAnnalisa Patrizi
May 16, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Alexander M FosterAndrew Johnston
Sep 10, 2017·The Journal of Allergy and Clinical Immunology·Jason E HawkesJames G Krueger
Oct 3, 2017·Acta Dermato-venereologica·Kazuhisa FurueMasutaka Furue
Jan 19, 2018·Therapeutic Advances in Chronic Disease·Jillian FriederAlan Menter

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