Widening the view on dispersant-pigment interactions in colloidal dispersions with saturation transfer difference NMR spectroscopy

Journal of the American Chemical Society
Agnieszka SzczygielJosé C Martins

Abstract

The application of Saturation Transfer Difference (STD) NMR spectroscopy for the characterization of dispersant particle interactions is introduced. STD NMR has hitherto been applied, with great success, to the characterization of ligand-protein interactions and is currently a standard tool in biomolecular NMR spectroscopy. Nevertheless, the STD NMR technique has so far not yet crossed the boundaries of the biomolecular field. Here, we demonstrate that in spite of clear differences between a protein binding site and the surface of a pigment nanoparticle, the latter can also be subjected to STD NMR analysis, allowing us to detect (screen for) binding ligands, discriminate ligand from nonligand, and obtain information on the binding epitope. The approach should be generally applicable as long as the nanoparticle is comprised of a dense network of hydrogens, implicating almost all organic molecular nanocrystals. Thus it provides a novel investigative tool for the study of dispersions that is highly complementary to existing ones.

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Citations

Apr 11, 2012·Chemical Reviews·Jingjing HuYiyun Cheng
Sep 10, 2010·Journal of the American Chemical Society·Libo ZhaoTongwen Xu
Jan 3, 2012·Drug Discovery Today·Anirban BhuniaSubhrangsu Chatterjee
Aug 21, 2013·RNA Biology·Kimberly A HarrisPaul F Agris
May 18, 2018·Magnetic Resonance in Chemistry : MRC·Yunzhi ZhangLeah B Casabianca
Feb 26, 2016·Nature Communications·Pilar García-GarcíaAvelino Corma
Nov 1, 2019·Israel Journal of Chemistry·Y Randika PereraNicholas C Fitzkee
Nov 28, 2018·The Journal of Physical Chemistry Letters·Yunzhi Zhang, Leah B Casabianca
Dec 29, 2020·Langmuir : the ACS Journal of Surfaces and Colloids·Hui Xu, Leah Beck Casabianca
Sep 28, 2021·Physical Chemistry Chemical Physics : PCCP·Janet Muzulu, Amit Basu

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