Widespread and tissue specific age-related DNA methylation changes in mice.

Genome Research
Shinji MaegawaJean-Pierre J Issa

Abstract

Aberrant methylation of promoter CpG islands in cancer is associated with silencing of tumor-suppressor genes, and age-dependent hypermethylation in normal appearing mucosa may be a risk factor for human colon cancer. It is not known whether this age-related DNA methylation phenomenon is specific to human tissues. We performed comprehensive DNA methylation profiling of promoter regions in aging mouse intestine using methylated CpG island amplification in combination with microarray analysis. By comparing C57BL/6 mice at 3-mo-old versus 35-mo-old for 3627 detectable autosomal genes, we found 774 (21%) that showed increased methylation and 466 (13%) that showed decreased methylation. We used pyrosequencing to quantitatively validate the microarray data and confirmed linear age-related methylation changes for all 12 genomic regions examined. We then examined 11 changed genomic loci for age-related methylation in other tissues. Of these, three of 11 showed similar changes in lung, seven of 11 changed in liver, and six of 11 changed in spleen, though to a lower degree than the changes seen in colon. There was partial conservation between age-related hypermethylation in human and mouse intestines, and Polycomb targets in embryonic st...Continue Reading

References

Dec 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·F Antequera, A Bird
Apr 21, 1995·Cell·P W LairdR Jaenisch
Jun 1, 1995·Current Opinion in Genetics & Development·S H Cross, A P Bird
Nov 1, 1993·Somatic Cell and Molecular Genetics·K MatsuoW Schaffner
Aug 23, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y YatabeD Shibata
May 16, 2002·Journal of the National Cancer Institute·Lanlan ShenJean-Pierre J Issa
Jun 4, 2002·Nature Reviews. Genetics·Peter A Jones, Stephen B Baylin
Aug 3, 2002·Oncogene·Melanie Ehrlich
Aug 3, 2002·Oncogene·Kyoung-Mee Kim, Darryl Shibata
Oct 2, 2003·Proceedings of the National Academy of Sciences of the United States of America·F A FeltusP M Vertino
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Mar 6, 2004·Cancer Metastasis Reviews·Yutaka Kondo, Jean-Pierre J Issa
Dec 2, 2004·Nature Reviews. Cancer·Jean-Pierre Issa
May 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Karen WoodsonElaine Lanza
Oct 8, 2005·Seminars in Oncology·Minoru Toyota, Jean-Pierre J Issa
Mar 3, 2006·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Donna RayBruce Richardson
Oct 31, 2006·Nature Genetics·Florian EckhardtStephan Beck
Jan 4, 2007·Nature Genetics·Martin WidschwendterPeter W Laird
Feb 27, 2007·Cell·Peter A Jones, Stephen B Baylin
Mar 17, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jean-Pierre J Issa
Mar 21, 2007·Proceedings of the National Academy of Sciences of the United States of America·Tibor RauchGerd P Pfeifer
Oct 12, 2007·Cell Biology and Toxicology·Yongmei XiaoGeorge Hammons
Feb 7, 2008·Digestive Diseases and Sciences·Wen-Jin DingYan-Shen Peng
Mar 6, 2009·Proceedings of the National Academy of Sciences of the United States of America·Kimberly D SiegmundDarryl Shibata

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Citations

Aug 11, 2011·Inflammatory Bowel Diseases·Alexandru V OlaruYuriko Mori
Mar 10, 2011·The Proceedings of the Nutrition Society·Elizabeth K LundIan T Johnson
Jul 26, 2011·The Proceedings of the Nutrition Society·Dianne FordLuisa A Wakeling
Feb 28, 2014·Journal of Developmental Origins of Health and Disease·M A Hernández-ValeroO Gorlova
Sep 24, 2011·Nature Reviews. Cancer·Stephen B Baylin, Peter A Jones
Feb 24, 2011·Nature Reviews. Rheumatology·Esteban Ballestar
Jul 5, 2011·Nature Structural & Molecular Biology·Subhajyoti De, Franziska Michor
Mar 7, 2013·Nature Structural & Molecular Biology·Yehudit Bergman, Howard Cedar
Feb 7, 2012·Proceedings of the National Academy of Sciences of the United States of America·James M Amos-LandgrafWilliam F Dove
Aug 14, 2013·Proceedings of the National Academy of Sciences of the United States of America·James WestAndrew E Teschendorff
Aug 7, 2013·Human Molecular Genetics·Andrew E TeschendorffStephan Beck
May 28, 2011·Journal of Experimental Botany·Célia Miguel, Liliana Marum
Apr 13, 2012·Nucleic Acids Research·Paraskevi SalpeaBruce H Howard
May 27, 2011·Genome Research·Agustin F FernandezManel Esteller
Mar 16, 2011·Acta Physiologica·J A McKay, J C Mathers
Feb 10, 2011·Cancer Research·Soledad NegrottoYogen Saunthararajah
Jun 5, 2010·PLoS Genetics·Elke GrönnigerFrank Lyko
Jul 7, 2011·PloS One·Sven BocklandtEric Vilain
Aug 23, 2011·PloS One·Taichun QinJean-Pierre J Issa
May 24, 2014·PloS One·Guy LudwigHoward Cedar
Aug 28, 2012·Epigenomics·Keith E LathamNora Engel
Jan 9, 2014·Reproduction : the Official Journal of the Society for the Study of Fertility·Benjamin B ParrottLouis J Guillette
Feb 5, 2014·Genome Biology·Carola Ingrid WeidnerWolfgang Wagner
Apr 10, 2013·Epigenomics·Jerome D Boyd-KirkupJing-Dong J Han
May 9, 2014·Epigenomics·Ian T Johnson, Nigel J Belshaw
Mar 13, 2012·Annual Review of Biochemistry·Howard Cedar, Yehudit Bergman
Jun 30, 2014·Journal of the National Cancer Institute·Faiza NoreenKaspar Truninger
Apr 6, 2012·Breast Cancer Research and Treatment·Anneke Q van HoeselDave S B Hoon

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