Widespread cortical morphologic changes in juvenile myoclonic epilepsy: evidence from structural MRI

Epilepsia
Lisa RonanMary Fitzsimons

Abstract

Atypical morphology of the surface of the cerebral cortex may be related to abnormal cortical folding (gyrification) and therefore may indicate underlying malformations of cortical development (MCDs). Using magnetic resonance imaging (MRI)-based analysis, we examined cortical morphology in patients with juvenile myoclonic epilepsy (JME). MRI data was collected for 24 patients with JME and 40 demographically matched healthy controls. FreeSurfer, an automated cortical surface reconstruction method, was applied to compare cortical morphology between patients and controls. Areas of anomalous cortical morphology were defined as regions of interest (ROIs) to contrast regional cortical parameters, such as surface area, average thickness, and mean curvature between patients and controls. In patients with JME, changes to cortical morphology were detected in several regions. In the left hemisphere, these were in insular and cingulate cortices, occipital pole, and middle temporal and fusiform gyri. In the right hemisphere, changes were detected in insular cortex, inferior temporal gyrus, and precuneus. Further analysis of ROIs revealed that these changes are related to differences in surface area rather than average cortical thickness. In...Continue Reading

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Oct 30, 2012·Journal of Neurology·Laura ZamarianEugen Trinka
May 8, 2015·Acta Neurologica Scandinavica·K M ParkS E Kim
Aug 16, 2013·Epilepsia·Saud AlhusainiMary Fitzsimons
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