Widespread expression of beta1 integrins in the developing chick retina: evidence for a role in migration of retinal ganglion cells

Developmental Biology
Gordon M CannD O Clegg

Abstract

During extension of axons, critical neuronal interactions with extracellular matrix (ECM) and other cells are thought to be mediated in part by heterodimeric beta1 integrin receptors. In this report, we examine the expression and function of beta1 integrins in the developing chick retina. Expression of the beta1 subunit, assayed by in situ hybridization and antibody staining of dissociated cells, was widespread in undifferentiated neuroepithelial cells, before the initiation of axons. Expression persisted in most retinal cell layers throughout embryonic development, during and after axon extension. The repertoire of beta1-associated alpha subunits was examined using reverse transcription-polymerase chain reaction. In addition to the alpha6 and alpha8 subunits previously reported, chick homologues of the alpha2 and alpha4 subunits were detected. Developmental Northern blots revealed varying patterns of integrin subunit expression and showed that expression of beta1 and the mRNAs of its associated alpha subunits are not always coregulated during retinal development. The timing and distribution of expression suggested that beta1 integrins may be involved in other developmental events in addition to axon extension. To address funct...Continue Reading

Citations

Jul 19, 2000·Mental Retardation and Developmental Disabilities Research Reviews·C A Walsh
Jul 11, 2000·The Journal of Comparative Neurology·H HeringS Kröger
Jun 6, 2009·Journal of Molecular Neuroscience : MN·Matthew M HarperDonald S Sakaguchi
Jun 9, 2005·Progress in Retinal and Eye Research·Ani V DasIqbal Ahmad
Jun 26, 2001·Brain Research. Brain Research Reviews·S Thanos, J Mey
Aug 14, 1999·Brain Research. Developmental Brain Research·A SkeithP J Linser
Jul 3, 2003·Molecular and Cellular Neurosciences·Sherry T HikitaDennis O Clegg
Aug 2, 2003·Progress in Retinal and Eye Research·Robert E MarcEnrica Strettoi
Nov 27, 2009·The Journal of Biological Chemistry·Guorong LiPedro Gonzalez
Jul 12, 2013·PloS One·Willi HalfterPaul Bernhard Henrich
Mar 8, 2014·Journal of Cell Communication and Signaling·Sunil K Parapuram, William Hodge
Mar 24, 2004·Seminars in Cell & Developmental Biology·S F OsterD W Sretavan
Apr 8, 2014·Comptes rendus biologies·Kim Tuyen Nguyen-Ba-Charvet, Alain Chédotal
Sep 15, 2004·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Kevin L WingerdDennis O Clegg
May 2, 2002·The Journal of Comparative Neurology·Sucai DongWilli Halfter
Nov 28, 2002·Developmental Dynamics : an Official Publication of the American Association of Anatomists·Ming Li, Donald S Sakaguchi
Jan 28, 2014·British Journal of Pharmacology·E GramageP Hitchcock
Apr 29, 2015·Glia·Andreas Faissner, Jacqueline Reinhard
Jul 18, 2015·Development, Growth & Differentiation·Vyacheslav A DyachukNelly A Odintsova
Feb 23, 2000·Molecular Cell Biology Research Communications : MCBRC·D O Clegg
Apr 13, 2000·Brain Research. Brain Research Reviews·J Mey, S Thanos
Jan 20, 2004·Developmental Biology·Ming LiDonald S Sakaguchi
Dec 8, 2004·Developmental Biology·Sergiu T LeuDennis O Clegg
Oct 7, 2004·Developmental Biology·Ming Li, Donald S Sakaguchi
Apr 1, 2008·Progress in Retinal and Eye Research·Lucia Galli-RestaElena Novelli

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