Widespread expression of perilipin 5 in normal human tissues and in diseases is restricted to distinct lipid droplet subpopulations.

Cell and Tissue Research
Merita HashaniBeate Katharina Straub

Abstract

Diseases associated with the accumulation of lipid droplets are increasing in western countries. Lipid droplet biogenesis, structure and degradation are regulated by proteins of the perilipin family. Perilipin 5 has been shown to regulate basal lipolysis in oxidative tissues. We examine perilipin 5 in normal human tissues and in diseases using protein biochemical and microscopic techniques. Perilipin 5 was constitutively located at small lipid droplets in skeletal myocytes, cardiomyocytes and brown adipocytes. In addition, perilipin 5 was detected in the epithelia of the gastrointestinal and urogenital tract, especially in hepatocytes, the mitochondria-rich parietal cells of the stomach, tubular kidney cells and ductal cells of the salivary gland and pancreas. Granular cytoplasmic expression, without a lipid droplet-bound localization was detected elsewhere. In cardiomyopathies, in skeletal muscle diseases and during hepatocyte steatogenesis, perilipin 5 was upregulated and localized to larger and more numerous lipid droplets. In steatotic human hepatocytes, perilipin 5 was moderately increased and colocalized with perilipins 1 and 2 but not with perilipin 3 at lipid droplets. In liver diseases implicated in alterations of mito...Continue Reading

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Citations

Jun 13, 2019·Canadian Journal of Gastroenterology & Hepatology·Flaminia FerriStefano Ginanni Corradini
Aug 8, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Toni PetanMaida Jusović
May 9, 2019·Cell and Tissue Research·Ivan Dimov, Morris F Maduro
Mar 22, 2019·Cancers·Anastasia AsimakopoulouRalf Weiskirchen
May 18, 2021·World Journal of Diabetes·Alla MitrofanovaAlessia Fornoni
Jun 3, 2021·International Journal of Molecular Sciences·Paola Berenice Mass SanchezAnastasia Asimakopoulos

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Methods Mentioned

BETA
biopsies
ELISA
electrophoresis
density gradient centrifugation
immunoprecipitation
biopsy
Transmission
electron microscopy
light microscopy

Software Mentioned

cellSens Entry
HomologyModell
Cell Sense
MASCOT
BLAST ( Basic Local Alignment Search Tool ) Browser

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