Widespread genetic incompatibility in C. elegans maintained by balancing selection

Science
Hannah S SeidelLeonid Kruglyak

Abstract

Natural selection is expected to eliminate genetic incompatibilities from interbreeding populations. We have discovered a globally distributed incompatibility in the primarily selfing species Caenorhabditis elegans that has been maintained despite its negative consequences for fitness. Embryos homozygous for a naturally occurring deletion of the zygotically acting gene zeel-1 arrest if their sperm parent carries an incompatible allele of a second, paternal-effect locus, peel-1. The two interacting loci are tightly linked, with incompatible alleles occurring in linkage disequilibrium in two common haplotypes. These haplotypes exhibit elevated sequence divergence, and population genetic analyses of this region indicate that natural selection is preserving both haplotypes in the population. Our data suggest that long-term maintenance of a balanced polymorphism has permitted the incompatibility to persist despite gene flow across the rest of the genome.

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Citations

Oct 10, 2013·Nature Reviews. Genetics·David L Stern
Jun 19, 2013·Proceedings of the National Academy of Sciences of the United States of America·Alivia DeyAsher D Cutter
Sep 10, 2011·Genome Biology and Evolution·Masatoshi Nei, Masafumi Nozawa
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Mar 14, 2009·PLoS Genetics·Matthew V Rockman, Leonid Kruglyak
Aug 24, 2012·PLoS Genetics·Gianni Liti, Edward J Louis
Dec 8, 2009·Genetics·J David Van Dyken, Michael J Wade
Oct 12, 2012·Genetics·Gregory MinevichOliver Hobert
Apr 4, 2014·BMC Genomics·Ismael A VergaraNansheng Chen

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