PMID: 8971811Nov 29, 1996Paper

Widespread increase in brain protein synthesis following acute immobilization stress in adult rat brain

Neuroscience Letters
V BaubetP Bobillier

Abstract

The autoradiographic method with [L-35S]methionine was used to determine the effects of a 2 h acute immobilization stress followed by a 4 h recovery on local rates of protein synthesis in the adult rat brain. Methionine incorporation into proteins was significantly increased (from 17 to 86%) in 37 out of the 39 analyzed brain structures. These results show that the stress-induced activation of the overall rate of brain protein synthesis may persist for at least 4 h after cessation of the stimulus even though the stress-related physiological variables have returned to basal levels. They suggest that increased protein synthesis may play a key role in the molecular events which lead to the neuronal plastic changes following an acute stress.

References

Oct 1, 1988·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·T T SoncrantS I Rapoport
May 1, 1985·Journal of Neuroscience Methods·P LestageP Bobillier
Aug 1, 1971·Journal of Psychiatric Research·J W Mason
Sep 1, 1974·The International Journal of Applied Radiation and Isotopes·S A CrossT Hesselbo
Aug 24, 1981·Life Sciences·A Lajtha, D Dunlop
Jul 7, 1993·Molecular and Cellular Biochemistry·P FonluptM Lagarde

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